Levels of asymmetrical dimethylarginine are predictive of brachial artery flow-mediated dilation 6 years later. The Cardiovascular Risk in Young Finns Study

Atherosclerosis
Hannu PäiväMarkus Juonala

Abstract

Plasma asymmetric dimethylarginine (ADMA) is a novel risk factor for atherosclerosis and has been observed to associate with endothelial function in cross-section studies. In the present study our aim was to investigate whether plasma ADMA levels are predictive of brachial artery endothelial function in a prospective setting. Using ultrasound we measured brachial artery flow-mediated dilation (FMD) both in 2001 and 2007 in 1808 healthy subjects aged 24-39 years at baseline. Plasma methylarginines were determined by isocratic high-pressure liquid chromatography in 2001. In a multivariable model adjusted with brachial diameter and conventional cardiovascular risk factors, baseline ADMA levels had a significant inverse association with FMD measured 6 years later (β±SE: -1.89±0.69%, P=0.006). We conclude that plasma ADMA can predict brachial artery FMD in subjects without prevalent atherosclerotic disease. These data suggest that plasma ADMA may have a determinative role in predicting endothelial function.

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Citations

Aug 31, 2011·Cardiology Research and Practice·Elizabeth A Ellins, Julian P J Halcox
Feb 11, 2012·Journal of the American Society of Hypertension : JASH·Dylan Burger, Rhian M Touyz
May 30, 2015·Journal of the American Heart Association·Peter WilleitRajiv Chowdhury
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Aug 16, 2016·The Science of the Total Environment·Lucía G Pruneda-AlvarezIván N Pérez-Maldonado

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