Levels of azithromycin and alpha-1 acid glycoprotein in serum in patients with community-acquired pneumonia.

Antimicrobial Agents and Chemotherapy
R BohteP J van den Broek

Abstract

After an oral dose of 500 mg of azithromycin in patients with community-acquired pneumonia, their serum concentrations ranged between 0.06 and 0.25 mg/liter during the first 12 hours; the calculated percentages of unbound drug varied between 45 and 86%. This study shows that in these patients, the total levels of azithromycin in serum are lower than those expected and that the percentage of bound drug is clinically irrelevant.

References

Mar 1, 1992·The Journal of Infection·A KuikkaV V Valtonen
Jan 1, 1990·The Journal of Antimicrobial Chemotherapy·G FouldsR B Johnson
Jan 1, 1988·British Journal of Clinical Pharmacology·J W Bins, H Mattie

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Citations

Dec 31, 1997·The Pediatric Infectious Disease Journal·M D Reed, J L Blumer
Jan 7, 2011·Journal of Clinical Pharmacology·Ighovwerha OfotokunEdward P Acosta
Oct 26, 2018·Research in Veterinary Science·Danielle A MzykRonald E Baynes

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