Levels of cellular DNA polymerases in synchronized bovine paravovirus-infected cells

Journal of Virology
C PritchardE R Stout

Abstract

Infection of synchronized bovine fetal spleen cells with bovine parvovirus results in changes in the levels and patterns of DNA polymerases alpha and gamma during the cell cycle. The pattern of DNA polymerase alpha activity closely paralled viral DNA synthesis and the production of progeny virus, and levels, of this enzyme were threefold greater than in mock-infected cells during the period of maximal viral DNA synthesis. DNA polymerase gamma activity remained slightly elevated during viral DNA replication. Levels and patterns of DNA polymerase beta were similar in mock- and virus-infected cells.

Related Concepts

Bos indicus
Cell Cycle
DNA, Double-Stranded
DNA Polymerase I
DNA Polymerase II
DNA Polymerase III
DNA Polymerase N3
DNA, Viral
Parvoviridae

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