Levels of chloroquine resistance in Plasmodium falciparum are determined by loci other than pfcrt and pfmdr1

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Levels of chloroquine resistance in Plasmodium falciparum are determined by loci other than pfcrt and pfmdr1

Abstract

Citations

Contribution of the pfmdr1 gene to antimalarial drug-resistance

Increased density but not prevalence of gametocytes following drug treatment of Plasmodium falciparum

Polymorphisms in cg2 and pfcrt genes and resistance to chloroquine and other antimalarials in vitro in Plasmodium falciparum isolates from Colombia

ABC transporters and drug resistance in parasitic protozoa

Malaria control and the evolution of drug resistance: an intriguing link

Physical linkage to drug resistance genes results in conservation of var genes among West Pacific Plasmodium falciparum isolates

Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum.

Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT

pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines.

Monitoring of malaria parasite resistance to chloroquine and sulphadoxine-pyrimethamine in the Solomon Islands by DNA microarray technology

Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene.

PfMDR1: mechanisms of transport modulation by functional polymorphisms.

The role of Pfmdr1 and Pfcrt in changing chloroquine, amodiaquine, mefloquine and lumefantrine susceptibility in western-Kenya P. falciparum samples during 2008-2011

Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.

Antimalarial drugs: modes of action and mechanisms of parasite resistance.

Frequency distribution of antimalarial drug resistance alleles among Plasmodium falciparum isolates from Gezira State, central Sudan, and Gedarif State, eastern Sudan.

Using the genome to dissect the molecular basis of drug resistance

Genetic mutations in pfcrt and pfmdr1 at the time of artemisinin combination therapy introduction in South Pacific islands of Vanuatu and Solomon Islands.

Spread and evolution of Plasmodium falciparum drug resistance

Quinoline-resistance reversing agents for the malaria parasite Plasmodium falciparum

pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum.

Multiple transporters associated with malaria parasite responses to chloroquine and quinine

Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross

Role of pfmdr1 mutations on chloroquine resistance in Plasmodium falciparum isolates with pfcrt K76T from Papua New Guinea

Synergism between Pfcrt and Pfmdr1 genes could account for the slow recovery of chloroquine sensitive Plasmodium falciparum strains in Ghana after chloroquine withdrawal

Prevalence of pfcrt point mutations and level of chloroquine resistance in Plasmodium falciparum isolates from Africa