Levels of endothelial nitric oxide synthase and calcitonin gene-related peptide in the Charcot foot: a pilot study

The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons
Javier La FontaineE B Jude

Abstract

The pathogenesis of Charcot neuroarthropathy is unclear. To investigate the possibility that decreased levels of calcitonin gene-related peptide and endothelial nitric oxide synthase are involved in the process, we studied bone samples from healthy subjects (n = 4), subjects with diabetic neuropathy (n = 4), and subjects with Charcot neuroarthropathy (n = 4). A statistically significant difference was found in endothelial nitric oxide synthase expression between bone specimens in patients with diabetic neuropathy, Charcot neuroarthropathy, and normal bone (P = .008). A trend toward calcitonin gene-related peptide intensification was observed in normal bone as compared to diabetic neuropathy and Charcot neuroarthropathy bone specimens, but it did not reached statistical significance (P = .23). This pilot study suggests that abnormal calcitonin gene-related peptide and endothelial nitric oxide synthase activity may play a role in the development of Charcot neuroarthropathy. 4.

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Citations

Oct 8, 2013·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Shafic Said Al-NammariSabokbar Afsie
Mar 8, 2012·Diabetic Foot & Ankle·Shelly A M Larson, Patrick R Burns
Aug 7, 2013·Diabetic Foot & Ankle·Gökhan KaynakTahir Oğüt
Oct 5, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N L Petrova, C M Shanahan
Jan 24, 2016·The Foot·Javier La FontaineEdward Jude
Aug 24, 2013·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Ajit Kumar Varma
Jan 15, 2013·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Naohiro ShibuyaDaniel C Jupiter
Jul 31, 2012·Medical Hypotheses·A B RahigudeP S Bhutada
Jun 28, 2011·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Javier La FontainePilar Valderrama
Mar 31, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·W J Jeffcoate
Mar 30, 2011·The International Journal of Lower Extremity Wounds·Robert BlakytnyEdward B Jude
Jun 21, 2018·Bone & Joint Research·S E Johnson-LynnA H N Robinson
Oct 4, 2017·Journal of Orthopaedic Surgery and Research·Hong-Mou ZhaoDing-Jun Hao
Aug 7, 2018·World Journal of Diabetes·Harsh DurgiaHenith Raj
May 7, 2019·Current Diabetes Reviews·Dario PitoccoAlfredo Pontecorvi
Aug 17, 2018·Current Diabetes Reports·Brian M Schmidt, Crystal M Holmes

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