PMID: 6405626May 11, 1983Paper

Levels of enzymes of energy metabolism are controlled by activity of cultured rat myotubes

The American Journal of Physiology
J C Lawrence, W J Salsgiver

Abstract

We have investigated the effects of inhibiting the spontaneous activity of cultured rat myotubes on several representative enzymes of glycolytic and oxidative metabolism. The results presented demonstrate that contractile activity in the absence of nerves can regulate the amounts of these enzymes and indicate that muscle activity may partially control development of the metabolic types of muscle fibers. Control muscle cells have relatively high levels of glycolytic enzymes and low oxidative enzymes and metabolically most closely resemble fast glycolytic fibers. The divalent cation ionophore A23187 caused enzyme levels of the cultured cells to change towards those found in tonically contracting skeletal muscle fibers in vivo. The evidence presented suggests that calcium may mediate certain of the effects associated with muscle contraction on enzymes of energy metabolism.

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Citations

Jan 1, 1990·Journal of Neurochemistry·A MartinuzziW K Engel
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Edward O OjukaJohn O Holloszy
Apr 1, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Edward O OjukaJohn O Holloszy
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Edward O OjukaJohn O Holloszy
Sep 10, 2003·Sports Medicine·Isabella IrrcherDavid A Hood
Jun 21, 2005·Annals of the New York Academy of Sciences·Tien-Shun YehRong-Hong Hsieh
Mar 4, 2005·Clinical and Experimental Pharmacology & Physiology·Masataka SuwaShuzo Kumagai
Aug 6, 2004·The Proceedings of the Nutrition Society·Edward O Ojuka
May 26, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M BishnoiS K Panchal
Jan 1, 1989·The American Journal of Physiology·S HatfaludyH H Vandenburgh
Aug 26, 1998·Biochimica Et Biophysica Acta·S C LearyC D Moyes
Oct 1, 1988·Respiration Physiology·S BlankC D Ianuzzo
Jan 18, 1985·Biochimica Et Biophysica Acta·J G ZuurveldH T van Moerkerk
Jan 24, 2008·Biochimica Et Biophysica Acta·Nina HankeHans-Peter Kubis

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