PMID: 602942Jan 1, 1977Paper

Levels of erythropoietin in patients with the anemias of chronic diseases and liver failure

American Journal of Hematology
S F WallnerH P Ward

Abstract

Two mechanisms are felt to be responsible for the production of anemia in patients with chronic diseases. The first is failure to produce adequate amounts of erythropoietin (EP), and the second is failure to deliver iron to the bone marrow in amounts sufficient to support normal erythropoiesis. In order to evaluate these hypotheses we studied urine and serum EP levels and levels of 2,3-diphosphoglycerate in normal subjects, in patients with the anemia of chronic diseases, in patients with chronic liver disease, and in patients with a variety of other anemias. Based on the results, we propose first that insufficient production of EP is one of the major mechanisms responsible for anemia in patients with chronic diseases. Second, insufficient production of EP is, in part, responsible for anemia seen in patients with chronic liver disease. Third, serum and urine EP levels decrease with aging, and this correlates with the fall of hemoglobin levels seen in older normal subjects.

References

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Citations

Dec 1, 1988·Mechanisms of Ageing and Development·M MoriF Takaku
Jul 16, 2002·Brain Research. Molecular Brain Research·Michael J RenziLinda K Jolliffe
Dec 1, 1994·Baillière's Clinical Haematology·A M Konijn
Jan 1, 1991·Journal of Internal Medicine·J CamachoJ J Vázquez
Sep 1, 1983·Postgraduate Medical Journal·D Samson
Sep 1, 1989·British Journal of Haematology·A JacobsT Lewis
Oct 1, 1982·Annals of the Rheumatic Diseases·R A WilliamsJ M Gumpel
Jan 1, 1981·American Journal of Hematology·D A LipschitzC Thompson
Apr 1, 1991·European Journal of Haematology·H K Boyd, T R Lappin
Aug 1, 1979·Scandinavian Journal of Haematology·V Pavlović-KenteraD Marinković

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