Levels of Fibrin Degradation Products at Admission With Acute Ischemic Stroke Correlate With the NIH Stroke Scale Score 1 h After Intravenous Thrombolysis.

Frontiers in Neurology
Bin ZhuZhigang Zhao

Abstract

Background: Fibrin degradation products (FDPs) are fragments released by the plasmin-mediated degradation of fibrinogen or fibrin. Whether plasma levels of these fragments can predict the thrombolytic effect of recombinant tissue plasminogen activator (r-tPA) remains unknown. Methods: We performed a hospital-based study of patients with acute ischemic stroke (AIS) to explore the relationship between FDP levels at admission and the NIH Stroke Scale (NIHSS) score 1 h after thrombolysis treatment. In this retrospective, single-center study, the data of all patients with AIS who received r-tPA treatment at Beijing Tiantan Hospital from January 2019 to October 2020 were collected and analyzed. Demographic and clinical data, including laboratory examinations, were also analyzed. Results: A total of 339 patients with AIS were included in this study. Of these, 151 showed favorable effects of r-tPA, and 188 showed unsatisfactory effects at 1 h after thrombolysis. Overall, we found an inverse relationship between the FDPs levels at admission and the NIHSS score. A significant difference was observed when using the interquartile range of the FDPs levels (1.31 μg/mL) as a cutoff value (P = 0.003, odds ratio [OR] = 1.95, 95% confidence inte...Continue Reading

References

Dec 13, 2005·Stroke; a Journal of Cerebral Circulation·Jeffrey L Saver
May 31, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Kai ZacharowskiPeter Petzelbauer
Feb 24, 2010·Journal of Internal Medicine·V MurrayP Wester
Jun 11, 2011·Current Opinion in Anaesthesiology·Carla JenneweinKai Zacharowski
Feb 6, 2017·Circulation Research·Luciana CataneseMarc Fisher
Mar 6, 2019·The American Journal of Medicine·Yunyun XiongMarc Fisher
Mar 18, 2019·Lancet Neurology·Simiao WuUNKNOWN China Stroke Study Collaboration
Oct 12, 2019·Nature Reviews. Disease Primers·Bruce C V CampbellGeoffrey A Donnan
Feb 10, 2020·Journal of Neuroradiology. Journal De Neuroradiologie·Yongtao GuoXinfeng Liu
Mar 3, 2020·Stroke; a Journal of Cerebral Circulation·Martha MarkoUNKNOWN Austrian Stroke Unit Registry Collaborators
Jun 5, 2020·Neuropsychiatric Disease and Treatment·Zheren ZhouYurong Zhang
Oct 31, 2020·Cellular and Molecular Neurobiology·Chengli LiuWei Wang
Dec 6, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Zihan ChangQing Wang

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