Levels of inflammatory cytokines from peripheral blood mononuclear cells of children with cow's milk protein allergy

Türk Pediatri Arşivi
Maria D'ApolitoMassimo Pettoello-Mantovani

Abstract

The aim of the study was to investigate the level of cytokines in cultures of cow's milk protein- stimulated peripheral blood mononuclear cells of patients with cow's milk protein allergy. Eleven children with cow's milk protein allergy and 11 non-allergic controls were studied. Their peripheral blood mononuclear cells were cultured alone and in the presence of cow's milk α-lactalbumin; β-lactoglobulin; αS 1, αS 2, β, and κ-casein fraction mixtures; and a cow's protein mixture from whole milk. Production of cytokines, tumor necrosis factor-α, interleukin-10, and interleukin-12 were determined in culture supernatants. In cow's milk protein-stimulated peripheral blood mononuclear cell cultures of children with cow's milk protein allergy, tumor necrosis factor-α, interleukin-10, and interleukin-12 production was significantly higher than in non-allergic controls (p<0.05). No difference in cytokine production was found between cultures obtained from unstimulated peripheral blood mononuclear cell cultures of both cow's milk protein allergy and non-allergic controls. The findings of this preliminary study align with data from the literature suggesting that the investigation of tumor necrosis factor-α, interleukin-10, and interleukin-...Continue Reading

Citations

Jul 16, 2020·Journal of Food Biochemistry·Meijia HuangYong Wu
Jul 11, 2019·Food Science & Nutrition·Eric Banan-Mwine DaliriDeog-Hwan Oh
Aug 15, 2019·Ocular Immunology and Inflammation·J NeilF Brignole-Baudouin

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