Levels of Inflammatory Cytokines IL-1β , IL-6, IL-8, IL-17A, and TNF-α in Aqueous Humour of Patients with Diabetic Retinopathy

Journal of Diabetes Research
Songfu FengLing Yuan

Abstract

Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. However, the role of inflammation in the pathogenesis of DR is not completely understood. This is an observational clinical research enrolling 80 type II diabetic patients who had undergone cataract surgeries either with DR or without DR. All cases were further categorized by the proliferative stages of retinal neovascularization and by the lengths of diabetic history. The levels of inflammatory cytokines including IL-1β, IL-6, IL-8, IL-17, and TNF-α in aqueous humour were tested. Results in this study indicated that these cytokine levels were increased in DR patients and might have a synergistic effect on the pathogenesis of this disease. They were also elevated along with the progression of neovascularization, reflecting the severity of DR. The results also suggested that for diabetic patients, the higher these levels are, the sooner retinal complications might appear. In conclusion, the levels of inflammatory cytokines IL-1β, IL-6, IL-8, IL-17A, and TNF-α in aqueous humour may be associated with the pathogenesis, severity, and prognosis of DR.

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Citations

Feb 14, 2020·Metabolomics : Official Journal of the Metabolomic Society·Dmitry V ChistyakovEvgeni Yu Zernii
Dec 22, 2019·Stem Cell Reviews and Reports·Barbora HermankovaVladimir Holan
Aug 11, 2020·Biochemia Medica·Snježana KaštelanAntonela Gverović Antunica
May 8, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Navid NeyshaburinezhadYalda H Ardakani
Nov 7, 2019·Clinical Science·Eoin P BrennanPhillip Kantharidis
Feb 21, 2021·International Ophthalmology·Ho RaJiwon Baek
May 1, 2021·International Journal of Molecular Sciences·Thomas E ZapadkaPatricia R Taylor
May 1, 2021·International Journal of Molecular Sciences·Giuliana ManninoDebora Lo Furno
Jun 1, 2021·Frontiers in Immunology·Xiongfeng PanAizhong Liu
Jul 4, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Edoardo MidenaElisabetta Pilotto
Oct 2, 2021·Frontiers in Pharmacology·Pengjuan MaYizhi Liu

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Methods Mentioned

BETA
Assay
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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