Levels of inflammatory cytokines in type 2 diabetes patients with different urinary albumin excretion rates and their correlation with clinical variables

Journal of Diabetes Research
Fen-Qin ChenQiu-Yue Wang

Abstract

Although the pathogenetic mechanism of DN has not been elucidated, an inflammatory mechanism has been suggested as a potential contributor. This study was designed to explore the relationship between low-grade inflammation and renal microangiopathy in T2DM. A total of 261 diabetic subjects were divided into three groups according to UAE: a normal albuminuria group, a microalbuminuria group, and a macroalbuminuria group. A control group was also chosen. Levels of hs-CRP, TNF-α, uMCP-1, SAA, SCr, BUN, serum lipid, blood pressure, and HbA1c were measured in all subjects. Compared with the normal controls, levels of hs-CRP, TNF-α, uMCP-1, and SAA in T2DM patients were significantly higher. They were also elevated in the normal albuminuria group, P < 0.05. Compared with the normal albuminuria group, levels of these inflammatory cytokines were significantly higher in the microalbuminuria and macroalbuminuria group, P < 0.01. The macroalbuminuria group also showed higher levels than the microalbuminuria group, P < 0.01. Also they were positively correlated with UAE, SBP, DBP, LDL-C, and TC. We noted no significance correlated with course, TG, or HDL-C. Only TNF-α; was positively correlated with HbA1c. This study revealed the importanc...Continue Reading

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Citations

Sep 17, 2014·Journal of the American Society of Hypertension : JASH·Seyed Reza MirhafezMajid Ghayour-Mobarhan
May 12, 2015·Journal of Diabetes Research·Francesca MagrinelliStefano Tamburin
Mar 5, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Fenqin ChenQiuyue Wang
Jul 5, 2017·Experimental and Therapeutic Medicine·Siwei ZhangDayun Sui

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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