Abstract
Although the pathogenetic mechanism of DN has not been elucidated, an inflammatory mechanism has been suggested as a potential contributor. This study was designed to explore the relationship between low-grade inflammation and renal microangiopathy in T2DM. A total of 261 diabetic subjects were divided into three groups according to UAE: a normal albuminuria group, a microalbuminuria group, and a macroalbuminuria group. A control group was also chosen. Levels of hs-CRP, TNF-α, uMCP-1, SAA, SCr, BUN, serum lipid, blood pressure, and HbA1c were measured in all subjects. Compared with the normal controls, levels of hs-CRP, TNF-α, uMCP-1, and SAA in T2DM patients were significantly higher. They were also elevated in the normal albuminuria group, P < 0.05. Compared with the normal albuminuria group, levels of these inflammatory cytokines were significantly higher in the microalbuminuria and macroalbuminuria group, P < 0.01. The macroalbuminuria group also showed higher levels than the microalbuminuria group, P < 0.01. Also they were positively correlated with UAE, SBP, DBP, LDL-C, and TC. We noted no significance correlated with course, TG, or HDL-C. Only TNF-α; was positively correlated with HbA1c. This study revealed the importanc...Continue Reading
References
Dec 1, 1994·Clinical Biochemistry·Y KumonK Hashimoto
Sep 5, 2001·Molecular Immunology·J E Volanakis
Mar 28, 2002·Diabetes·Coen D A StehouwerHans-Henrik Parving
Dec 31, 2002·Journal of Diabetes and Its Complications·Tsukasa MoriiSeiki Ito
Apr 30, 2003·Diabetes Care·Richard L KleinUNKNOWN DCCT/ECIC STUDY GROUP
Aug 21, 2003·Diabetologia·M SaraheimoP-H Groop
Jul 29, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sergio MezzanoJesús Egido
Jun 7, 2005·Journal of the American Society of Nephrology : JASN·Michele Dalla VestraPaola Fioretto
Sep 29, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Juan F Navarro, Carmen Mora
Jan 25, 2006·Journal of Molecular and Cellular Cardiology·Yao-Jen LiangLing-Ping Lai
Mar 1, 2006·Journal of Diabetes and Its Complications·Kohzo TakebayashiToshihiko Inukai
Aug 29, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Juan F NavarroJavier García
Feb 22, 2007·Kidney International·X DongM D Griffin
Jun 6, 2007·Current Diabetes Reports·Michael D Williams, Jerry L Nadler
Sep 28, 2007·Diabetes Research and Clinical Practice·Atsuyo FujitaKishio Nanjo
Oct 31, 2007·Diabetologia·S GiuntiG Gruden
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Christiane Ruster, Gunter Wolf
Nov 23, 2007·European Journal of Pharmacology·Eun Seok KangHyun Chul Lee
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Pawel P WolkowAndrzej S Krolewski
Mar 11, 2008·Thrombosis and Haemostasis·Didier HanriotDan Longrois
Apr 5, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gang Jee KoDae Ryong Cha
May 29, 2008·Endocrine Journal·Aysen AkalinBanu Sensoy
Nov 17, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Charumathi SabanayagamE Shyong Tai
Jun 15, 2011·Nutrition & Metabolism·Vivian SoetiknoKenichi Watanabe
Jul 12, 2011·Diabetologia·F LiuH Y Lan
Sep 29, 2011·Archives of Medical Research·Graciela Zambrano-GalvanFernando Guerrero-Romero
Nov 2, 2011·Acta Diabetologica·José Manuel Fernández-RealMartí Vallès
Mar 17, 2012·Clinical Biochemistry·Hala O El MesallamyAmira S Ahmed
Citations
Sep 17, 2014·Journal of the American Society of Hypertension : JASH·Seyed Reza MirhafezMajid Ghayour-Mobarhan
May 12, 2015·Journal of Diabetes Research·Francesca MagrinelliStefano Tamburin
May 12, 2016·Immunobiology·Wisitsak PhoksawatChanvit Leelayuwat
Jul 28, 2016·Journal of Ethnopharmacology·Fazlin Mohd FauziAndreas Bender
Feb 13, 2019·Nutrients·Xiaofeng WangJianping Wu
Mar 5, 2020·PloS One·Liliane Silvano AraújoJuliana Reis Machado
Jun 10, 2017·Journal of Diabetes Research·Kayleigh GriffithsGareth J McKay
Mar 5, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Fenqin ChenQiuyue Wang
Mar 23, 2019·Frontiers in Immunology·Belal ChamiPaul K Witting
Jul 5, 2017·Experimental and Therapeutic Medicine·Siwei ZhangDayun Sui