Levels of interferon in blood serum and toxicity studies of bacteria-derived bovine alpha I1 interferon in dairy calves.

Journal of Clinical Microbiology
J H GillespieV T Scialli

Abstract

This paper reports information on the levels of interferon (IFN) in the blood serum of dairy calves given 10(6) U of bacteria-derived bovine alpha I1 interferon per kg of body weight by intravenous (i.v.), intramuscular (i.m.), subcutaneous (s.c.), and intranasal (i.n.) routes. Highest levels (10,000 U/ml) in the vesicular stomatitis viral assay system were obtained after i.v. administration and occurred within 30 min of a dose; levels rapidly declined thereafter to a low of 200 to 300 U/ml by 24 h. Serum inhibitory activity against vesicular stomatitis virus in this range is sometimes found in normal dairy calves. Levels after i.m. and s.c. administration were similar: a plateau of 1,000 to 2,000 U/ml between 2 and 8 h after a treatment with a decline to 200 to 300 U/ml by 24 h. Serum IFN was not detected after i.n. dosing or in the control group given physiological buffered saline by the i.m. route. A transitory moderate febrile response, but no other clinical adverse effects, was noted after the first intramuscular dose of IFN, but not after subsequent i.m. doses. No clinical signs were noted after i.v., s.c., or i.n. dosing or in the control calves given physiological buffered saline intramuscularly. After i.v., s.c., and i...Continue Reading

References

Aug 1, 1978·Infection and Immunity·R W Fulton, S K Root
Jan 1, 1974·Archiv für die gesamte Virusforschung·A W McClurkinR L Smith
Mar 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·H Diderholm, Z Dinter

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Citations

Nov 7, 2006·The Journal of Veterinary Medical Science·Hiromichi OhtsukaSeiichi Kawamura
Dec 15, 2015·Frontiers in Veterinary Science·Artur Summerfield, Nicolas Ruggli
Dec 1, 1986·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·J GillespieE Schiff
May 18, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A SummerfieldK C McCullough

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