Levels of Intestinal Inflammation and Fibrosis in Resection Specimens after Preoperative Anti-Tumor Necrosis Factor Alpha Treatment in Patients with Crohn's Disease: A Comparative Pilot Study

Surgery Research and Practice
J TorleAlaa El-Hussuna

Abstract

Strictures are a common complication in Crohn's disease (CD), found in more than 50% of patients. They are characterized by the excessive deposition of extracellular proteins in the tissue as a result of the chronic inflammatory process. The effect of anti-tumor necrosis factor alpha (TNF-α) therapy on the development of fibrosis is not yet fully understood. To investigate whether the degree of intestinal inflammation and fibrosis is correlated with preoperative anti-TNF-α) therapy on the development of fibrosis is not yet fully understood. This unblinded, prospective, single tertiary center, pilot cohort study included all adult patients with CD who underwent elective, laparoscopic, or open intestinal resection. Preoperative investigations included measurement of blood TNF-α) therapy on the development of fibrosis is not yet fully understood. Histopathological specimens from 10 patients with CD who underwent ileocecal or ileocolic resections were retrieved. Four of those patients were on anti-TNF-α) therapy on the development of fibrosis is not yet fully understood. α) therapy on the development of fibrosis is not yet fully understood. α) therapy on the development of fibrosis is not yet fully understood. p=0.01). Anti-TNF-α) ...Continue Reading

References

Oct 22, 2011·Clinical and Experimental Gastroenterology·M Cottone, V Criscuoli
Oct 25, 2012·Digestion·Alain M SchoepferChristian Mottet
Sep 14, 2013·Digestive Diseases·Florian Rieder, Claudio Fiocchi
Nov 22, 2013·PloS One·Mário Henrique M BarrosGerald Niedobitek
Apr 1, 2014·Fibrogenesis & Tissue Repair·Dominik Bettenworth, Florian Rieder
Jul 25, 2017·Frontiers in Medicine·Gerhard Rogler, Martin Hausmann
Jan 24, 2018·Journal of Crohn's & Colitis·Marijn C VisschedijkEleonora A M Festen

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