Levels of PBDEs in plasma of juvenile starlings (Sturnus vulgaris) from British Columbia, Canada and assessment of PBDE metabolism by avian liver microsomes

The Science of the Total Environment
Claudio A ErraticoJohn E Elliott

Abstract

In this study, the levels of polybrominated diphenyl ethers (PBDEs), HO-PBDEs, and bromophenols were monitored in starling chick plasma samples collected in Delta (British Columbia, Canada) close to the Vancouver municipal landfill and in Glen Valley, a rural area in British Columbia. The in vitro formation of hydroxylated metabolites of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and 2,2',4,4',5-pentabromodiphenyl ether (BDE-99) was also investigated using starling chick liver microsomes. Total PBDE plasma levels were approximately 60 times higher in starling chicks from Delta than from Glen Valley, suggesting that the Delta site is a major source of PBDEs for the local population of starlings and that PBDEs previously measured in starling eggs are bioavailable to chicks. In both locations, BDE-47 and BDE-99 were the two major congeners present at similar concentrations, suggesting contamination with the Penta-BDE mixture. Among the several possible hydroxylated metabolites of PBDEs monitored in starling plasma, only 2,4,5-tribromophenol was detected and its levels did not exceed 18±7 pg/mL. Also, several hydroxylated metabolites of BDE-47 and BDE-99 were formed by starling chick liver microsomes, but in low amounts. Therefore...Continue Reading

References

Aug 30, 2005·Environmental Science & Technology·John E ElliottBryan Wakeford
Oct 13, 2005·Environmental Pollution·Michael G IkonomouZachary L Hickman
Jun 24, 2008·The Science of the Total Environment·Anne P VonderheideGwendolyn L Welsh
Jul 24, 2008·Toxicology and Applied Pharmacology·Gerardo R MarchesiniAlbertinka J Murk
May 11, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Claudio A ErraticoStelvio M Bandiera
Jun 16, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Claudio A ErraticoStelvio M Bandiera
Jun 29, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Claudio A ErraticoStelvio M Bandiera

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