Levels of piribedil and its active metabolite (S-584) in the rat striatum.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
R FanelliS Garattini

Abstract

1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.

References

Apr 5, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·R J Miller, L L Iversen
May 1, 1969·European Journal of Pharmacology·M LaubieJ C Le Douarec
Dec 1, 1971·The Journal of Pharmacy and Pharmacology·H CorrodiU Ungerstedt
Nov 1, 1972·European Journal of Pharmacology·H CorrodiU Ungerstedt
Nov 1, 1968·Journal of Medicinal Chemistry·G L RegnierJ C Le Douarec

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.