Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjogren's syndrome

Annals of the Rheumatic Diseases
P VogelsangS Appel

Abstract

Sjögren's syndrome (SS) is a lymphoproliferative autoimmune disease, characterised by dryness of the mouth and eyes. Dendritic cells (DC) are potent antigen-presenting cells crucial for initiating and maintaining primary immune responses. This study quantified interferon-producing plasmacytoid DC (pDC) and two myeloid DC subsets (mDC1 and mDC2) in peripheral blood (PB) from primary SS (pSS) patients and healthy controls. Blood samples from 31 pSS patients and 28 gender and age-matched healthy controls were analysed by flow cytometry using the Miltenyi Blood DC enumeration kit. The presence of pDC in salivary glands (SG) from pSS patients was analysed by immunohistochemistry. Patients with pSS had significantly less pDC and mDC2 in PB compared with healthy controls. Moreover, pDC are present in SG from patients with pSS. Patients with pSS have alterations among DC populations in PB, and pDC are present in the SG, suggesting a potential role of these cells in SS.

Citations

Jun 13, 2013·Mucosal Immunology·A-H Hovav
Jan 11, 2011·Arthritis Research & Therapy·Ewa A SzyszkoKathrine Skarstein
Sep 20, 2011·Acta Histochemica Et Cytochemica·An LeArthur R Hand
Mar 20, 2015·Expert Review of Clinical Immunology·Alireza GhanadanNima Rezaei
Mar 24, 2010·Respiratory Research·Geert R Van PottelbergeGuy G Brusselle
Feb 24, 2012·PLoS Pathogens·Rocio Castro-SeoanePeter-Christian Klöhn
Jan 24, 2013·Journal of Leukocyte Biology·Caroline HémontRégis Josien
Jan 24, 2014·Expert Review of Clinical Immunology·Maarten R HillenJoel A Van Roon
Sep 26, 2020·Journal of Clinical Medicine·Richard WitasCuong Q Nguyen
Jul 28, 2020·Progress in Retinal and Eye Research·Arsia JamaliPedram Hamrah
Mar 12, 2017·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Hawra AljanobiJill M Kramer
Dec 5, 2020·International Journal of Molecular Sciences·Amrita Srivastava, Helen P Makarenkova
Apr 1, 2014·Journal of Endometriosis and Pelvic Pain Disorders·David E MaridasMarina Berbic
Jan 25, 2022·Scandinavian Journal of Immunology·Roland Jonsson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Malin V Jonsson, Kathrine Skarstein
Scandinavian Journal of Immunology
P VogelsangS Appel
© 2022 Meta ULC. All rights reserved