Levels of polyunsaturated fatty acids in tissues from zinc-deficient rats fed a linseed oil diet

Lipids
K Eder, M Kirchgessner

Abstract

The effect of zinc deficiency on the levels of n-6 and n-3 polyunsaturated fatty acids (PUFA) in lipids from tissues of rats fed a diet containing linseed oil was investigated. Rats were fed either a control diet (25 mg Zn/kg) or a zinc-deficient diet (0.8 mg Zn/kg) for 10 d. To avoid energy and nutrient deficiency, 11.6 g of diet per day was administered by gastric tube. At the end of the experiment, rats fed the zinc-deficient diet had drastically reduced plasma zinc concentration and alkaline phosphatase activity consistent with severe zinc deficiency in these rats. Zinc-deficient rats had higher levels of n-3 PUFA, in particular eicosapentaenoic acid (EPA), and lower levels of n-6 PUFA, in particular linoleic acid, in liver and plasma phosphatidylcholine (PC) and in erythrocyte membrane total lipids than did control rats. By contrast, the levels of n-3 PUFA in PC from testes and heart, and in phosphatidylethanolamine (PE) from liver, testes and heart, were only slightly different between zinc-deficient and control rats. The study suggests that desaturation of alpha-linolenic acid is not inhibited by zinc deficiency, and that in zinc-deficient rats, n-3 PUFA preferentially incorporated into phospholipids at the expense of n-...Continue Reading

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Citations

Aug 1, 1996·Biological Trace Element Research·K Eder, M Kirchgessner
Apr 11, 2002·Lipids·N N GomezM S Gimenez
Aug 21, 2004·Biological Chemistry·Hannelore Daniel, Heike tom Dieck
Jan 22, 2008·Biological Trace Element Research·Takafumi Norii
May 12, 1998·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·A VilletA Favier
Jan 15, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Neha Singla, D K Dhawan
Dec 6, 2017·Molecular Nutrition & Food Research·Alexandra SchutkowskiGabriele I Stangl
Dec 22, 2006·The British Journal of Nutrition·Nidia Noemí GomezMaría Sofía Gimenez

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