Levels of retinyl palmitate and retinol in the skin of SKH-1 mice topically treated with retinyl palmitate and concomitant exposure to simulated solar light for thirteen weeks

Toxicology and Industrial Health
Jian YanP P Fu

Abstract

Retinyl esters account for more than 70% of the endogenous vitamin A found in human skin, and retinyl palmitate is one of the retinyl esters in this pool. Human skin is also exposed to retinyl palmitate exogenously through the topical application of cosmetic and skin care products that contain retinyl palmitate. To date, there is limited information on the penetration and distribution of retinyl palmitate and vitamin A within in the skin. In this study, the accumulation of retinyl palmitate and generation of retinol in the skin of male and female SKH-1 mice that received repeated topical applications of creams containing 0.0%, 0.1%, 0.5%, 1.0%, 5.0%, 10%, or 13% of retinyl palmitate 5 days a week for a period of 13 weeks were studied. Because products containing retinyl palmitate are frequently applied to sun-exposed skin, and because it is well established that exposure to sunlight and UV light can alter cutaneous levels of retinoids, mice in this study were additionally exposed 5 days a week to simulated solar light. The results showed that retinyl palmitate diffused into the skin and was partially hydrolyzed to retinol. The levels of retinyl palmitate in the skin of mice that were administered retinyl palmitate cream were hi...Continue Reading

References

Jan 1, 1992·Critical Reviews in Food Science and Nutrition·E S Tee
Jan 1, 1990·The Journal of Investigative Dermatology·H Törmä, A Vahlquist
Dec 1, 1984·The Journal of Investigative Dermatology·B BerneA Vahlquist
Jan 21, 2000·Dermatology : International Journal for Clinical and Investigative Dermatology·O SorgJ Saurat
Aug 18, 2001·Toxicology and Applied Pharmacology·R L SamsP C Howard
Jan 8, 2004·The Journal of Investigative Dermatology·Christophe AntilleJean-Hilaire Saurat
Aug 19, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nan MeiTao Chen
May 24, 2006·Toxicology and Industrial Health·Jian YanPeter P Fu
Mar 21, 2007·Vitamins and Hormones·Peter P FuWayne G Wamer
Jun 20, 2007·Photochemistry and Photobiology·Peter P FuWayne G Wamer

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Citations

Apr 23, 2005·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·P P FuP C Howard
Aug 10, 2010·Journal of the American Academy of Dermatology·Steven Q WangHenry W Lim
Oct 20, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Nan MeiTao Chen
Jul 11, 2009·Biomedical Chromatography : BMC·Luciana B Lopes, Rachel Reed
Aug 2, 2015·Applied Microbiology and Biotechnology·Seung-Hye HongDeok-Kun Oh
Jan 15, 2010·Burns : Journal of the International Society for Burn Injuries·Matthias C AustPeter M Vogt
Oct 14, 2017·International Journal of Toxicology·Wilbur Johnson
Sep 13, 2013·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Peter P FuHsiu-Mei Chiang

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