PMID: 15374161Sep 1, 1996Paper

Levels of serum creatinine and estimated creatinine clearance over the age of 75: a study of an elderly Swedish population

Archives of Gerontology and Geriatrics
J FastbomB Winblad

Abstract

Serum creatinine was measured and creatinine clearance estimated using the Cockcroft-Gault (C-G) formula, in elderly people participating in a population study of the elderly, the Kungsholmen Project. This is an ongoing longitudinal study which was begun in 1987 and comprised all people in a district of Stockholm, born in 1912 or earlier. Out of 2368 people 1810 participated. In 1362 cases, serum creatinine and an estimation of the creatinine clearance could be obtained. The mean age of these elderly people was 81 years, and 92% were living in their own homes. A linear regression model showed that the weight of the elderly decreased by age, indicating a decrease in muscle mass. However, this was not accompanied by a decrease in serum creatinine levels. When creatinine clearance was estimated using the C-G formula, a significant decline with age was seen at an average rate of 1.2 ml/min per year. It declined from 52 ml/min at age 75 to 27 ml/min at age 95. The mean for the whole study group was 44.6 ml/min. Our data suggest that the glomerular filtration rate may be very low in the oldest old and that there is a continuing decline with increasing age, even in a population where a high number of the elderly are still living in th...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Aug 1, 1987·Archives of Internal Medicine·T H Goldberg, M S Finkelstein
Mar 1, 1974·Circulation Research·N K HollenbergJ P Merrill

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Citations

Apr 22, 2004·QJM : Monthly Journal of the Association of Physicians·E RimonS Levy
Jul 26, 2008·Archives of Gerontology and Geriatrics·M SanakaS Mineshita
Jan 1, 1996·Journal of the American Geriatrics Society·P WillsB Winblad
Apr 1, 2010·Nephrology·S ChadbanUNKNOWN CARI
Oct 27, 2007·The British Journal of Nutrition·Stig AndersenPeter Laurberg
Jun 19, 2004·Scandinavian Journal of Urology and Nephrology·Ingela Fehrman-Ekholm, Lars Skeppholm

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