Levels of Serum Phosphorus and Cardiovascular Surrogate Markers

Journal of Atherosclerosis and Thrombosis
Jinwei WangLuxia Zhang

Abstract

This study aimed to evaluate the cross-sectional association between serum phosphorus and arterial stiffness among a health checkup population. The study population included 26791 individuals without impaired kidney function. Arterial stiffness was measured by brachial-ankle pulse wave velocity (baPWV), ankle brachial index (ABI), and augmentation index (AI) by the radial artery waveform analysis. Linear or logistic regression model was used to appropriately evaluate the association between phosphorus levels and arterial stiffness markers. The mean age of the population was 49 years and 67% were male. The phosphorus level was divided into quintiles. After multivariate adjustments, participants in the fourth (3.90-4.17 mg/dL) and fifth quintile (≥ 4.18 mg/dL) of serum phosphorus had increased the level of baPWV with linear regression coefficients of 11.9 [95% confidence interval (CI): 5.6-18.2] and 17.2 (95% CI: 10.9-23.5), respectively, compared with those in the first quintile (<3.34 mg/dL). No significant associations were found between each quintile of phosphorus and ABI <0.9. However, participants in the fifth quintile of phosphorus had an increased risk of ABI ≥ 1.3 with an odds ratio (OR) of 1.2 (95% CI: 1.0-1.5) compared...Continue Reading

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Citations

Aug 1, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wenwei BaiJuan Liu
Jul 5, 2017·Journal of Atherosclerosis and Thrombosis·Kentaro WatanabeShinichi Nishi
Jun 13, 2017·Journal of Atherosclerosis and Thrombosis·Junichiro Hashimoto

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