Levels of Systemic Low-grade Inflammation in Pregnant Mothers and Their Offspring are Correlated

Scientific Reports
Nadia Rahman FinkHans Bisgaard

Abstract

High sensitivity C-reactive protein (hs-CRP) is a marker of systemic low-grade inflammation and associated with chronic inflammatory diseases. It is unknown whether maternal and infant hs-CRP levels are correlated and little is known about risk factors in early childhood. Hs-CRP were measured in mothers during pregnancy week 24 (N = 690), and one-week postpartum (N = 675) and in their children age 6 mo (N = 640) enrolled in the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) cohort. The risk factor analysis included anthropometrics, environmental exposures and CRP-Genetic Risk Score (GRS). Mother's body mass index (BMI), use of antibiotics, smoking, cesarean delivery and season were associated with higher maternal hs-CRP level, whereas higher social circumstances were associated with lower hs-CRP level (p < 0.05). Child's BMI, siblings, bacterial airway colonization, current infection, CRP-genetic risk score and season were associated with higher hs-CRP at age 6 mo (all p < 0.05). Mother's hs-CRP level in pregnancy week 24 was associated with hs-CRP level in the child at 6 mo: β-coefficient = 0.11 [95% CI: 0.01-0.20], R2 = 0.22, p = 0.03. The association was unchanged adjusted for all significant risk fac...Continue Reading

References

Feb 1, 1991·Obstetrics and Gynecology·D H WattsD A Eschenbach
Aug 1, 1990·British Journal of Obstetrics and Gynaecology·W J de VilliersF C de Beer
Oct 18, 2002·European Journal of Internal Medicine·Hans Ablij, Arend Meinders
Jun 25, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·R XiaoD A Luthy
Nov 2, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Luís BeloIrene Rebelo
Oct 12, 2007·The New England Journal of Medicine·Hans BisgaardChristian Bressen Pipper
Mar 23, 2011·Nature Immunology·Harald RenzDirk Haller
Aug 30, 2011·World Journal of Pediatrics : WJP·Karen L LeibowitzNicolas Stettler
Oct 5, 2013·American Journal of Respiratory and Critical Care Medicine·Nadja H VissingHans Bisgaard
Oct 15, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H BisgaardK Bønnelykke
Feb 4, 2014·Psychoneuroendocrinology·Lilly ShanahanShawn Bauldry
Jan 13, 2015·The Journal of Allergy and Clinical Immunology·Bo L K ChawesHans Bisgaard
May 27, 2015·Acta Physiologica·C IngvorsenL I Hellgren
Nov 20, 2015·The Journal of Allergy and Clinical Immunology·Anna Hammerich ThysenSusanne Brix
Apr 21, 2016·Obesity·Romy GaillardMatthew W Gillman
Oct 30, 2016·The Journal of Pediatrics·Pilar NavarroLeandro Soriano-Guillén
Sep 15, 2016·American Journal of Respiratory and Critical Care Medicine·Jakob StokholmHans Bisgaard
Dec 29, 2016·The New England Journal of Medicine·Hans BisgaardKlaus Bønnelykke
Nov 23, 2017·Frontiers in Endocrinology·Marisol Castillo-Castrejon, Theresa L Powell

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Citations

Jul 31, 2020·European Journal of Nutrition·M Selma-RoyoM C Collado
Apr 8, 2020·Journal of Medical Ethics·Bruce Philip Blackshaw, Daniel Rodger
Nov 2, 2021·Frontiers in Immunology·Anders Hagen JarmundAnn-Charlotte Iversen

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Methods Mentioned

BETA
cesarean section

Software Mentioned

ggplot2
R

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