Leveraging computational genomics to understand the molecular basis of metal homeostasis.

The New Phytologist
Nicolas Grosjean, Crysten E Blaby-Haas

Abstract

Genome-based data is helping to reveal the diverse strategies plants and algae use to maintain metal homeostasis. In addition to acquisition, distribution and storage of metals, acclimating to feast or famine can involve a wealth of genes that we are just now starting to understand. The fast-paced acquisition of genome-based data, however, is far outpacing our ability to experimentally characterize protein function. Computational genomic approaches are needed to fill the gap between what is known and unknown. To avoid misconstruing bioinformatically derived data, which is the root cause of the inaccurate functional annotations that plague databases, functional inferences from diverse sources and contextualization of that evidence with a robust understanding of protein family evolution is needed. Phylogenomic- and comparative-genomic-based studies can aid in the interpretation of experimental data or provide a spark for the discovery of a new function. These analyses not only lead to novel insight into a target protein's function but can generate thought-provoking insights across protein families.

References

Oct 27, 1997·The Journal of Biological Chemistry·G SchwarzR R Mendel
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·R OverbeekN Maltsev
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·M PellegriniT O Yeates
Jun 11, 1999·Molecular Microbiology·N C Kyrpides, C A Ouzounis
Dec 11, 1999·Nucleic Acids Research·H M BermanP E Bourne
Jan 29, 2000·The Plant Journal : for Cell and Molecular Biology·S K FreyermuthJ C Polacco
Apr 5, 2000·Biochimica Et Biophysica Acta·M L Guerinot
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·S ThomineJ I Schroeder
Jun 3, 2000·Nature Biotechnology·M Y Galperin, E V Koonin
Jun 24, 2000·Nature·D EisenbergT O Yeates
Dec 29, 2000·Nature·UNKNOWN Arabidopsis Genome Initiative
Apr 6, 2001·Plant Molecular Biology·C P WitteM A Taylor
Jun 13, 2001·Plant Physiology·K B Axelsen, M G Palmgren
Aug 14, 2001·Plant Physiology·P MäserM L Guerinot
Apr 5, 2002·Trends in Genetics : TIG·Itai YanaiCharles DeLisi
Apr 6, 2002·Science·Stephen A GoffSteven Briggs
Dec 10, 2002·Molecular Genetics and Genomics : MGG·M BacanamwoJ C Polacco
Mar 26, 2003·Plant Molecular Biology·Vicente SancenónLola Peñarrubia
Jun 5, 2003·The Plant Cell·Toshiharu ShikanaiMarinus Pilon
Jun 14, 2003·Plant Physiology·Ivan BaxterKristian B Axelsen
May 18, 2004·Bioinformatics·Harm van BakelCisca Wijmenga
Jun 25, 2004·Nucleic Acids Research·Aron Marchler-Bauer, Stephen H Bryant
Jul 15, 2004·PLoS Biology·Matthew Hurles
Nov 13, 2004·The Plant Cell·Elizabeth P Colangelo, Mary Lou Guerinot
Mar 18, 2005·The Plant Cell·Salah E Abdel-GhanyToshiharu Shikanai
May 19, 2005·Journal of the American Chemical Society·Robert M CicchilloSquire J Booker
Jun 22, 2005·FEBS Letters·Sandrine Ollagnier-de ChoudensMarc Fontecave

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Indian Journal of Medical Research
Ching- Wan Lam
Pacific Symposium on Biocomputing
Quaid MorrisOliver Stegle
Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Kiyoshi Takayama
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
M Moritani, M Itakura
© 2021 Meta ULC. All rights reserved