Leveraging machine learning techniques for predicting pancreatic neuroendocrine tumor grades using biochemical and tumor markers

World Journal of Clinical Cases
Rui-Quan ZhouRong Liu

Abstract

The incidence of pancreatic neuroendocrine tumors (PNETs) is now increasing rapidly. The tumor grade of PNETs significantly affects the treatment strategy and prognosis. However, there is still no effective way to non-invasively classify PNET grades. Machine learning (ML) algorithms have shown potential in improving the prediction accuracy using comprehensive data. To provide a ML approach to predict PNET tumor grade using clinical data. The clinical data of histologically confirmed PNET cases between 2012 and 2018 were collected. A method of minimum P for the Chi-square test was used to divide the continuous variables into binary variables. The continuous variables were transformed into binary variables according to the cutoff value, while the P value was minimum. Four classical supervised ML models, including logistic regression, support vector machine (SVM), linear discriminant analysis (LDA) and multi-layer perceptron (MLP) were trained by clinical data, and the models were labeled with the pathological tumor grade of each PNET patient. The performance of each model, including the weight of the different parameters, were evaluated. In total, 91 PNET cases were included in this study, in which 32 were G1, 48 were G2 and 11 w...Continue Reading

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Methods Mentioned

BETA
biopsy
surgical resection
pancreatectomy

Software Mentioned

SVM
scikit
lsqr
Python
Anaconda
SPSS
LDA
eigen
learn

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