Levetiracetam-Induced Seizure Aggravation in Patients With Focal Cortical Dysplasia

Clinical Neuropharmacology
Emilija CvetkovskaGordana Kiteva Trencevska

Abstract

The choice of antiepileptic drug is typically based on seizure type, and there is no evidence for superior effectiveness or potential deterioration of particular antiepileptic drug in specific etiologic subgroups. The aim of the study was to identify etiological factor(s) associated with increased risk of seizure aggravation with levetiracetam (LEV). A retrospective analysis of 139 patients treated with LEV was performed. Seizure aggravation was defined as a 100% or greater increase in seizures frequency, which occurred within 1 month of drug introduction. Five patients who fulfilled the selection criteria were identified. Seizure aggravation occurred with low doses (500-1000 mg) of LEV. In addition to increased frequency and duration, 2 patients developed new seizure types. Withdrawal of LEV resulted in seizure return to background frequency in all patients. Four of 5 patients have distinctive magnetic resonance imaging finding of focal cortical dysplasia. No patients with paradoxical effect of LEV were detected in the idiopathic epilepsy group or other types of symptomatic epilepsies. Our results suggest that LEV may possibly induce seizure exacerbation in a subset of patients with focal cortical dysplasia-related epilepsy, a...Continue Reading

References

May 13, 1998·Epilepsia·E PeruccaO Dulac
Dec 24, 2002·Seizure : the Journal of the British Epilepsy Association·Karl O NakkenSvein I Johannessen
May 21, 2010·Epileptic Disorders : International Epilepsy Journal with Videotape·Roberto H CaraballoCecilia De los Santos
Jun 18, 2011·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Stéphane AuvinCatherine Chiron
Sep 20, 2012·Seizure : the Journal of the British Epilepsy Association·Yong-Hong LiuGang Zhao
Jun 12, 2014·Acta Neuropathologica·Imad M NajmGiorgio Lo Russo
Mar 27, 2015·Annals of Neurology·Z Irene WangAndreas V Alexopoulos
Jul 13, 2016·Clinical Neuropharmacology·Chiara FoisGianPietro Sechi
Oct 26, 2016·CNS Drugs·Wolfgang LöscherHenrik Klitgaard
Jan 24, 2018·Neuropathology and Applied Neurobiology·I M NajmI Blümcke

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Citations

Jun 14, 2019·Clinical Neuropharmacology·Ernest R Somerville
Mar 26, 2021·Rinshō shinkeigaku = Clinical neurology·Takeshi InoueRyosuke Takahashi

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