Levitated single-droplet drying: case study with itraconazole dried in binary organic solvent mixtures

International Journal of Pharmaceutics
Eva WulstenGeoffrey Lee

Abstract

The objective of this case study of the single-droplet drying of two itraconazole/polymer formulations was to determine how the solvent system influences drying rate and dried particle morphology. A clear dual functionality of the two solutes could be identified. The polymeric component (PVP or HPMC) determined drying rate, whereas the drug determined end particle morphology. This could be related to solubilities of the two components in the binary solvent mixtures used. The formulation of a surface skin early on in drying only occurred with HPMC and strongly influenced drying rate but not dried particle morphology.

References

Dec 8, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Patrice Tewa-TagneHatem Fessi

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Citations

Apr 20, 2013·Drug Development and Industrial Pharmacy·Anke Sass, Geoffrey Lee
Jun 28, 2011·Drug Development and Industrial Pharmacy·Marjana DürriglJelena Filipović-Grčić
Feb 24, 2011·Journal of Pharmaceutical Sciences·Sateesh Kumar SathigariR Jayachandra Babu
Dec 22, 2015·International Journal of Pharmaceutics·Feng Wan, Mingshi Yang
Jul 24, 2012·International Journal of Pharmaceutics·Amrit PaudelGuy Van den Mooter
Mar 28, 2017·Advances in Colloid and Interface Science·Duyang ZangXingguo Geng
Oct 21, 2020·Foods·Tri Thanh NguyenCristina Ratti
Nov 5, 2019·International Journal of Pharmaceutics·Wangding LuMingshi Yang

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