Levocarnitine normalizes elevated blood level of soluble Fas mRNA in patients with acute myocardial infarction

Bulletin of Experimental Biology and Medicine
D V NovikovV V Novikov

Abstract

Fas-induced apoptosis plays an important role in the mechanisms of tissue injury in myocardial infarction. The level of membrane Fas mRNA was elevated during the postinfarction period in the blood of patients and did not change in response to levocarnitine. The mRNA level of soluble Fas, inhibiting Fas-dependent apoptosis, remained normal during the first 7 days, but increased 14 days after myocardial infarction, which corresponded to previously detected increase of serum level of soluble Fas molecules. Addition of levocarnitine, inhibiting Fas-dependent apoptosis, to therapy caused no changes in the level of soluble Fas mRNA, presumably because of similar effects of soluble Fas and levocarnitine on the apoptotic processes in myocardial infarction.

References

Jul 1, 1993·Biulleten' eksperimental'noĭ biologii i meditsiny·E A FrolovaA B Syrkin
Oct 29, 2002·Journal of Clinical Pathology·P A J KrijnenH W M Niessen
Oct 17, 2008·Coronary Artery Disease·Quan-Zhou FengEltyeb Abdelwahid
Jul 28, 2011·Biochemical and Biophysical Research Communications·Eri OyanagiJunzo Sasaki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis