Levocetirizine is an effective treatment in patients suffering from chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, parallel, multicenter study

International Journal of Dermatology
A Kapp, W J Pichler

Abstract

Chronic idiopathic urticaria (CIU) is defined by the almost daily presence of urticaria for at least 6 weeks without an identifiable cause. Symptoms include short-lived wheals, itching, and erythema. CIU impedes significantly a patient's quality of life (QoL). Levocetirizine is an antihistamine from the latest generation approved for CIU. To investigate the efficacy of levocetirizine, 5 mg, and placebo for the symptoms and signs of CIU, as well as for the QoL and productivity. The primary criteria of evaluation were the pruritus severity scores over 1 week of treatment and over 4 weeks. The QoL was assessed via the Dermatology Life Quality Index (DLQI). Baseline pruritus severity scores were comparable in the two treatment groups (2.06+/-0.58). After 1 week, levocetirizine was superior to placebo and demonstrated a considerable efficacy (difference=0.78, P<0.001). This efficacy was maintained over the entire study period (4 weeks, P<0.001). The number and size of wheals were considerably reduced compared with placebo over 1 week and over the total treatment period (P <or= 0.001). This was paralleled by an improvement in the QoL (DLQI: 7.3 units in the levocetirizine group and 2.4 units in the placebo group) and a higher product...Continue Reading

References

Feb 1, 1995·The British Journal of Dermatology·A Y Finlay, E C Coles
May 1, 1994·Clinical and Experimental Dermatology·A Y Finlay, G K Khan
Dec 13, 2000·Statistics in Medicine·J A Barber, S G Thompson
Aug 10, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·D WilliamsonA Y Finlay
Jan 5, 2002·The Journal of Investigative Dermatology. Symposium Proceedings·T ZuberbierB M Henz
Jan 5, 2002·The Journal of Investigative Dermatology. Symposium Proceedings·T ZuberbierB M Henz
May 16, 2002·International Journal of Dermatology·Gwendoline KiebertDavid Fivenson
Jan 9, 2003·The American Journal of Medicine·F Estelle R Simons
Sep 13, 2003·British Journal of Clinical Pharmacology·Ashok PurohitNelly Frossard
Sep 23, 2003·Current Opinion in Allergy and Clinical Immunology·Malcolm W Greaves
Oct 2, 2003·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·K J DenhamM K Church
Nov 18, 2003·Allergy·T Zuberbier
Apr 16, 2004·The Journal of Investigative Dermatology. Symposium Proceedings·Victoria Lewis, Andrew Y Finlay

❮ Previous
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Citations

Jun 8, 2012·Clinical Reviews in Allergy & Immunology·Katherine Altman, Christopher Chang
Apr 1, 2011·International Journal of Pharmaceutical Investigation·Prabhakara PrabhuRn Charyulu
Nov 1, 2011·Expert Opinion on Pharmacotherapy·Jean-Paul Ortonne
Jun 7, 2011·Expert Opinion on Drug Metabolism & Toxicology·Marta Ferrer
Jul 25, 2008·Current Medical Research and Opinion·J-J Grob, J-M Lachapelle
Dec 14, 2011·European Journal of Internal Medicine·Jean-Paul Ortonne
Aug 3, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Susan D MathiasKarin E Rosén
Jan 23, 2015·The Journal of Investigative Dermatology·Antoinette I M van LaarhovenAndrea W M Evers
Sep 24, 2009·Allergy·T ZuberbierB Wedi
Oct 1, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·J-B LiuH Zhou
Dec 19, 2014·International Journal of Dermatology·Madhulika JohnsonEmy A Thomas
Mar 19, 2008·Expert Opinion on Pharmacotherapy·Garry M Walsh
Nov 8, 2013·Expert Opinion on Pharmacotherapy·Michael MakrisTorsten Zuberbier
Apr 29, 2014·The Journal of Allergy and Clinical Immunology·Jonathan A BernsteinDana Wallace
Nov 15, 2014·The Cochrane Database of Systematic Reviews·Maulina SharmaBen Carter
Mar 19, 2008·Clinical Drug Investigation·Christine De VosRossen Boev
Feb 5, 2015·Archivos de cardiología de México·Juan Calderón-ColmeneroMiguel Beltrán Gámez
Mar 6, 2010·Postgraduate Medicine·Luz FonacierBora Kim
Jan 8, 2014·The Cochrane Database of Systematic Reviews·Clive E AdamsKarla Soares-Weiser
Mar 29, 2014·The Cochrane Database of Systematic Reviews·Sue WoodwardPauline Chiarelli
Aug 12, 2009·Expert Opinion on Pharmacotherapy·Francesca ScordamagliaGiorgio Walter Canonica
Jul 26, 2008·Postgraduate Medicine·Donald A Bukstein, Thomas J Lapine
Sep 12, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Phichayut PhinyoMati Chuamanochan
Jan 4, 2013·The World Allergy Organization Journal·Mario Sánchez-BorgesUNKNOWN WAO Scientific and Clinical Issues Council
Dec 15, 2020·Dermatology Research and Practice·Sushil PaudelSudarshan Paudel

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