PMID: 56427Dec 2, 1975

Levodopa alone and in combination with a peripheral decarboxylase inhibitor benserazide (Madopar) in the treatment of Parkinson's disease: A controlled clinical trial

Journal of Neurology
U K RinneJ Presthus


A combination of levodopa and the extracerebrally acting decarboxylase inhibitor benserazide (ratio 4:1) (Madopar), was compared with levodopa alone in a controlled double-blind clinical multicenter trial on 94 patients with Parkinson's disease. During 4 months of therapy levodopa + benserazide proved superior to levodopa on several accounts. Nausea and vomiting occurred with statistically significant less severity and frequency. Clinical improvement expressed through improvement in Webster rating occurred sooner and was all together greater. The treatment schedules did not differ with regard to other side effects, in particular involuntary movements and reduction in supine blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters.


Apr 9, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Stewart A Factor
Aug 1, 1975·Acta Neurologica Scandinavica·E Birket-Smith
May 1, 1976·Acta Neurologica Scandinavica·H PakkenbergU K Rinne
Jan 1, 1979·Current Medical Research and Opinion·B O Williams, D Carlyle
Jun 8, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·J E Ahlskog, M D Muenter
Oct 23, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Oscar S Gershanik
Mar 11, 2018·The Journal of Pharmacology and Experimental Therapeutics·Nicolas VeyresPhilippe Huot
Jul 1, 1978·Acta Neurologica Scandinavica·E Birket-SmithB Mikkelsen


Aug 1, 1975·Acta Neurologica Scandinavica·E Birket-Smith
Jan 1, 1972·Zeitschrift für Neurologie·U K RinneT Sirtola
Jan 1, 1974·Acta Neurologica Scandinavica·E Birket-Smith
Nov 8, 1969·Lancet·D B CalneD R Laurence
Mar 19, 1973·Archiv für Psychiatrie und Nervenkrankheiten·E SchneiderH Maxion
Jan 1, 1973·European Neurology·U K RinneT Siirtola
Jan 1, 1968·European Neurology·U K Rinne, V Sonninen
Sep 1, 1969·British Journal of Pharmacology·D B CalneM Sandler
Jan 1, 1969·Psychopharmacologia·J ConstantinidisF Geissbuhler
Mar 1, 1971·Clinical Pharmacology and Therapeutics·A Pletscher, G Bartholini
Oct 1, 1969·Archives of Neurology·M D YahrM M Hoehn

Related Concepts

Kidney Function Tests
Decarboxylase Inhibitor [EPC]
Diastolic Blood Pressure
Aromatic Amino Acid Decarboxylase Inhibitors
Decarboxylase inhibitor
Etat Marbre
Nausea and Vomiting

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