Levodopa-carbidopa may improve vision loss in indirect traumatic optic neuropathy

Journal of Neurotrauma
M Reza RazeghinejadMohammadhadi Bagheri

Abstract

To compare the effect of levodopa-carbidopa on the visual outcome of patients with indirect traumatic optic neuropathy (ITON), this randomized, double-blind, placebo-controlled study was conducted on 32 patients with ITON within 6 days after trauma. Patients underwent a complete ocular examination, pattern visual evoked potential (PVEP) testing, and high-resolution orbital computed tomography (CT) scanning. All patients received high-dose intravenous methylprednisolone, and levodopa was also administered to the levodopa group. The main outcome measures were best corrected visual acuity and PVEP results at the last-completed examination. The study was completed on 16 patients in the levodopa group and 10 patients in the placebo group because the others were lost to follow-up. There were no statistically significant differences for age, sex, involved eye, ocular and CT scan findings, pretreatment visual acuity, frequency of recordable PVEPs, and follow-up. In the levodopa group the visual acuity improved significantly after treatment (p = 0.009), but not in the placebo group (p = 0.34). After treatment the visual acuity in the levodopa group was 2.1 ± 2.1, and in the placebo group was 3.9 ± 1.2 (p = 0.008). In those who had visua...Continue Reading

References

Jun 1, 1992·The British Journal of Ophthalmology·J A MaurielloL Frohman
Dec 15, 1990·American Journal of Ophthalmology·T C SpoorM J Wilkinson
Jan 1, 1988·Acta neurochirurgica·W MillesiJ Funder
Sep 1, 1982·The Journal of Comparative Neurology·J M FrederickJ G Hollyfield
Jan 1, 1994·International Ophthalmology Clinics·J S Berestka, J F Rizzo
May 1, 1994·Survey of Ophthalmology·K D Steinsapir, R A Goldberg
Apr 1, 1996·Archives of Otolaryngology--head & Neck Surgery·M W CookE F Pinczower
Jan 6, 2000·Current Opinion in Ophthalmology·K D Steinsapir
Feb 24, 2001·The Laryngoscope·B LübbenU Grenzebach
Jun 8, 2001·Plastic and Reconstructive Surgery·B H WangP N Manson
Jun 13, 2002·Acta Ophthalmologica Scandinavica·Thomas-Michael WohlrabJ P de Carpentier
Jan 7, 2003·The Laryngoscope·A ThakarD A Tandon
Sep 21, 2004·Ophthalmic Plastic and Reconstructive Surgery·Mark D Holmes, Bryan S Sires
Feb 1, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Morteza EntezariMasoumeh Sanagoo
Aug 2, 2007·Ophthalmic Plastic and Reconstructive Surgery·Cassandra B OnofreyRoy Casiano
Apr 7, 2009·Journal of Pediatric Ophthalmology and Strabismus·Subhash DadeyaK P S Malik
Jan 5, 2010·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Alok ThakerAshok K Mahapatra

❮ Previous
Next ❯

Citations

Jan 14, 2016·Military Medical Research·Eric L SingmanTimothy McCulley
Oct 21, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Deanna P LyttleRichard W Madsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology
C LanL Zeng
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Mitsuya IkejiriShintaro Suehiro
Journal of Pediatric Ophthalmology and Strabismus
L E LeguireM L McGregor
© 2021 Meta ULC. All rights reserved