Levodopa-induced dyskinesia and rotational behavior in hemiparkinsonian rats: independent features or components of the same phenomenon?

Behavioural Brain Research
Spiridon Konitsiotis, Christos Tsironis

Abstract

Chronic daily administration of 6.25mg/kg of levodopa in unilaterally 6-OHDA lesioned rats did not induce any observable behavioral effects for the first 12.5+/-2.5 days. Thereafter, levodopa administration induced abnormal involuntary movements (AIMs), involving the contralateral limb, head, neck and trunk, along with the development of contralateral rotations. AIMs and rotations followed a progressively worsening, highly correlated, parallel course. We suggest that rotational behavior does not represent a pure antiparkinsonian response, but along with levodopa-induced dyskinesia is part of the levodopa-induced motor response complications syndrome.

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Citations

Jun 19, 2012·Medical & Biological Engineering & Computing·Hsiao-Yu LeeJia-Jin J Chen
Jul 31, 2007·The Journal of Pharmacology and Experimental Therapeutics·Daniel B PuttermanSteven W Johnson
Jan 31, 2013·Experimental Neurology·Nicolas MorinThérèse Di Paolo
Mar 11, 2008·Behavioural Brain Research·Claudio Da CunhaNewton Sabino Canteras
Apr 30, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Christos TsironisSpiridon Konitsiotis
Nov 17, 2010·Fundamental & Clinical Pharmacology·Brigitte SpinnewynMichel Auguet
Dec 24, 2009·Journal of Neuroscience Research·Shu-Jing ZhangLei Chen
Jun 14, 2012·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Rosa Q SoWarren M Grill
Jan 16, 2013·Pharmacological Reviews·Philippe HuotJonathan M Brotchie
Nov 5, 2019·Frontiers in Neurology·Qiwei PengYan Xu

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