Levodopa-induced dyskinesia is closely linked to progression of frontal dysfunction in PD

Neurology
Han Soo YooPhil Hyu Lee

Abstract

To assess the relationship between the development of levodopa-induced dyskinesia (LID) and longitudinal changes in cognition. In this retrospective cohort study, we recruited 119 patients with Parkinson disease (PD) who underwent baseline and follow-up neuropsychological evaluations and were treated with levodopa for >5 years. On the basis of LID development, the patients were classified as patients with LID (PD-LID+, n = 38) or without LID (PD-LID-, n = 81) within 5 years of levodopa administration. After adjusting for age, sex, years of education, body mass index, motor severity at baseline, and levodopa increment per year, we compared the rates of cognitive decline using linear mixed model and dementia conversion using survival analysis between the groups. Neuropsychological performances and the percentage of patients with mild cognitive impairment (MCI) at baseline did not differ between the groups. The PD-LID+ group showed faster declines in frontal executive function (p = 0.002) and global cognitive function. The conversion rate to dementia was significantly higher in the PD-LID+ group than in the PD-LID- group (adjusted hazard ratio [HR] 3.94, 95% confidence interval [CI] 1.76-8.82). Patients with MCI in the PD-LID+ gro...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jun 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·W R Gibb, A J Lees
Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Jan 1, 1987·Movement Disorders : Official Journal of the Movement Disorder Society·N QuinnC D Marsden
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Feb 1, 2000·Journal of Neurology·F GrandasC Tabernero
Mar 29, 2000·Brain : a Journal of Neurology·G FénelonM Ziégler
Oct 26, 2000·Brain : a Journal of Neurology·A Schrag, N Quinn
Jun 8, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·J E Ahlskog, M D Muenter
Mar 14, 2003·Archives of Neurology·Dag AarslandPer Kragh-Sørensen
Jul 9, 2003·Annals of the New York Academy of Sciences·Stanley Fahn
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Nov 10, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Adrian M Owen
Mar 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam R Aron, Russell A Poldrack
May 23, 2006·Lancet Neurology·Lonneke M L de Lau, Monique M B Breteler
May 25, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Carmen Cristea JanvinKenneth Hugdahl
Dec 22, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Bruno DuboisMurat Emre
Jun 5, 2010·Brain Pathology·G Stennis Watson, James B Leverenz
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Mar 9, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Antonio CerasaAldo Quattrone
Jan 26, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Irene LitvanMurat Emre
Feb 11, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Minyoung OhChong Sik Lee
May 14, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Angus D MacleodCarl E Counsell
Jun 13, 2014·Journal of Neurology·Jee Hyun HamPhil Hyu Lee
Aug 31, 2014·Neurology·Julius B M AnangRonald B Postuma
Nov 22, 2014·Brain : a Journal of Neurology·Antonio CerasaAldo Quattrone
Mar 4, 2017·Nature Reviews. Neurology·Dag AarslandClive Ballard
Apr 30, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Roopa RajanAsha Kishore
Jul 25, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Su Jin ChungPhil Hyu Lee
Aug 8, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S J ChungY H Sohn

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Citations

Feb 8, 2020·Annals of Clinical and Translational Neurology·Seok Jong ChungPhil Hyu Lee
Jun 6, 2019·Frontiers in Neurology·Xun ZhouLiangjuan Fang
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna PierzchlińskaMonika Białecka

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