Levodopa-responsive breathing discomfort in Parkinson's disease patients

Journal of Neural Transmission
Nicola TambascoPaolo Calabresi

Abstract

In Parkinson's disease (PD), respiratory disturbances have been reported and the effect of levodopa on respiratory function remains controversial. The objective of this study was to evaluate pulmonary function utilizing spirometric and subjective evaluations in mild to moderated PD. Thirty-four consecutive sporadic PD patients (Hoehn and Yahr scale: 1-3) were prospectively evaluated using clinimetric scales, spirometry and modified Borg scale, all in off- and on-conditions. To check the respiratory function, a follow-up was performed at 4 years in a subgroup of these patients. Spirometric results were normal for all patients in both the on- and off-conditions at baseline. After levodopa administration, in addition to a significant improvement in subjective state of breathing discomfort, the mean forced expiratory volume in 1 s (FEV1), vital capacity (VC), forced vital capacity (FVC) values and their mean percentages predicted values (FEV1%, VC%, FVC%) were significantly increased (p < 0.05). Moreover, residual volume, total lung capacity, and the FEV1/FVC ratio were not significantly different for the ON and OFF conditions. At 4-year follow-up no resulting variations in the baseline values for FEV1%, FVC% or VC% were revealed. ...Continue Reading

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Citations

Nov 5, 2019·Expert Review of Respiratory Medicine·Marie Carmen ValenzaIrene Cabrera-Martos
Jan 17, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Srimathy VijayanFrank L Mastaglia
May 19, 2020·Expert Review of Neurotherapeutics·Srimathy VijayanFrank L Mastaglia
Apr 15, 2020·Experimental Neurology·Epiphani C SimmonsRick G Schnellmann
Jun 3, 2021·Brain Sciences·Any Docu AxeleradAnca Elena Gogu
Jan 21, 2021·Respiration; International Review of Thoracic Diseases·Laura López-LópezMarie Carmen Valenza
Dec 7, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N G DudchenkoO S Levin

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