Levofloxacin inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells.

Antimicrobial Agents and Chemotherapy
Mutsuo YamayaRyoichi Nagatomi

Abstract

Respiratory virus infections, including infections with rhinoviruses (RVs), are related to exacerbations of chronic obstructive pulmonary disease (COPD). A new quinolone antibiotic, levofloxacin (LVFX), has been used to treat bacterial infections that cause COPD exacerbations as well as bacterial infections that are secondary to viral infection in COPD patients. However, the inhibitory effects of LVFX on RV infection and RV infection-induced airway inflammation have not been studied. We examined the effects of LVFX on type 14 rhinovirus (RV14) (a major human RV) infection of human tracheal epithelial cells pretreated with LVFX. LVFX pretreatment reduced the RV14 titer, the level of cytokines in the supernatant, the amount of RV14 RNA in the cells after RV14 infection, and the cells' susceptibility to RV14 infection. LVFX pretreatment decreased the mRNA level of intercellular adhesion molecule 1 (ICAM-1), a receptor for RV14, in the cells and the concentration of the soluble form of ICAM-1 in the supernatant before RV14 infection. LVFX pretreatment also decreased the number and the fluorescence intensity of the acidic endosomes from which RV14 RNA enters the cytoplasm. LVFX pretreatment inhibited the activation of nuclear factor...Continue Reading

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Jun 15, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mutsuo YamayaRyoichi Nagatomi
Oct 14, 2010·European Journal of Pharmacology·Mutsuo YamayaRyoichi Nagatomi
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Citations

May 15, 2013·Respiratory Research·Laura Amado-RodríguezGuillermo M Albaiceta
Jan 15, 2014·Current Allergy and Asthma Reports·Maria PassiotiNikolaos G Papadopoulos
Aug 15, 2013·Seminars in Cell & Developmental Biology·Dolores D MrukC Yan Cheng
Dec 18, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A Dalhoff
Oct 23, 2018·Infectious Disorders Drug Targets·Muhammad Faraz AnwarSyed Ali
Aug 16, 2019·Clinical Microbiology Reviews·Joaquim Ruiz
Jul 17, 2021·Fundamental & Clinical Pharmacology·Rania AlaaeldinMoustafa Fathy

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