Levofloxacin treatment failure in a patient with fluoroquinolone-resistant Streptococcus pneumoniae pneumonia

Pharmacotherapy
Michael B KaysGerald A Denys

Abstract

The frequency of fluoroquinolone-resistant Streptococcus pneumoniae has increased as fluoroquinolone administration for treatment of respiratory tract infections has increased. Levofloxacin treatment failed in a patient who had pneumococcal pneumonia and had received three previous courses of levofloxacin therapy. Susceptibility testing revealed high-level resistance to levofloxacin (minimum inhibitory concentration [MIC] > 32 microg/ml), and cross-resistance to moxifloxacin (MIC 4 microg/ml), trovafloxacin (6 microg/ml), and gatifloxacin (12 microg/ml). Sequencing of the quinolone-resistance determining region revealed a mutation of serine-81 to phenylalanine (Ser81-->Phe) in the gyrA region of DNA gyrase and a Ser79-->Phe mutation in the parC region of topoisomerase IV The patient was treated successfully with intravenous ceftriaxone followed by oral cefprozil. Clinicians must be aware of local resistance patterns and the potential for fluoroquinolone treatment failures in patients with infections caused by S. pneumoniae.

References

Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G W Wortmann, S P Bennett
May 8, 2000·The Journal of Antimicrobial Chemotherapy·E O MasonP G Ambrose
May 29, 2000·The Journal of Antimicrobial Chemotherapy·J BroskeyR Warren
Sep 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R N Jones, M A Pfaller
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J G BartlettM J Fine
Jan 3, 2001·The New England Journal of Medicine·C G WhitneyUNKNOWN Active Bacterial Core Surveillance Program of the Emerging Infections Program Network
Feb 22, 2001·Antimicrobial Agents and Chemotherapy·C JanoirL Gutmann
Mar 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P L HoR M Chan
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·M S NiedermanUNKNOWN American Thoracic Society
Jun 21, 2001·The Annals of Pharmacotherapy·P E EmpeyM E Evans

❮ Previous
Next ❯

Citations

Dec 14, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M W R PletzK P Klugman
Dec 14, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J D FullerD E Low
Feb 8, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J Garau
Jan 17, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jack B AnonUNKNOWN Sinus And Allergy Health Partnership
Dec 20, 2003·Lancet·Thomas M File
Oct 12, 2002·Diagnostic Microbiology and Infectious Disease·Ronald N Jones, Lionel A Mandell
Oct 12, 2002·Diagnostic Microbiology and Infectious Disease·Ronald N JonesSusan C Nicholson
Apr 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick G P CharlesUNKNOWN Australian CAP Study Collaboration
Sep 24, 2004·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·C E NordR Leclercq
Oct 22, 2003·The Pediatric Infectious Disease Journal·Michael R Jacobs
Dec 23, 2003·The Pediatric Infectious Disease Journal·Jay M Lieberman
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Jeff PowisUNKNOWN Canadian Bacterial Surveillance Network
Oct 26, 2012·Interdisciplinary Perspectives on Infectious Diseases·Axel Dalhoff
Jan 21, 2003·Emerging Infectious Diseases·W Michael Scheld
May 3, 2014·International Journal of Antimicrobial Agents·Hartmut M Lode
May 28, 2005·Expert Review of Anti-infective Therapy·Mark A ZacharekMichael S Benninger
Apr 14, 2011·Expert Opinion on Emerging Drugs·Vicenç FalcóJordi Rello
Jan 10, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D E Low
May 4, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J CarrataláC García-Rey
May 4, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F Alvarez-LermaM Alvarez-Beltrán
Nov 10, 2006·Médecine et maladies infectieuses·E Denes
May 30, 2009·Pharmacotherapy·Annie Wong-BeringerJean Pallares
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Thomas M File
Jan 5, 2005·Diagnostic Microbiology and Infectious Disease·Sujata M BhavnaniPaul G Ambrose
Nov 3, 2004·International Journal of Antimicrobial Agents·K P KlugmanK Weiss
Sep 14, 2004·The American Journal of Medicine·Thomas M File
May 4, 2004·The Journal of Laboratory and Clinical Medicine·Charles Feldman
Apr 26, 2006·The American Journal of Emergency Medicine·Gregory A VolturoRichard Aghababian
Feb 11, 2005·Journal of Chemotherapy·F Alvarez-LermaUNKNOWN Study Group on Levofloxacin Use in the ICU
Nov 24, 2004·Infectious Disease Clinics of North America·Joshua P Metlay
Nov 24, 2004·Infectious Disease Clinics of North America·Thomas M File, Michael S Niederman
Dec 7, 2010·Aesthetic Surgery Journal·Michael A LaneBernard C Camins
Aug 19, 2003·The Annals of Pharmacotherapy·Jerome J SchentagAlan Forrest
Jun 9, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vincent T Andriole
Jun 7, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey D Fuller, Donald E Low
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lance R Peterson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Related Papers

The New England Journal of Medicine
John J RossSherwood L Gorbach
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Kevin B AndersonDonald E Low
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jay C ButlerFred C Tenover
© 2022 Meta ULC. All rights reserved