Oct 12, 2010

Levomepromazine for schizophrenia

The Cochrane Database of Systematic Reviews
Parthipan SivaramanMahesh Jayaram

Abstract

Levomepromazine is an 'older' typical antipsychotic medication licensed for use in schizophrenia but sparingly prescribed in the United Kingdom. To determine the clinical effects and safety of levomepromazine compared with placebo or antipsychotic medications for schizophrenia and schizophreniform psychoses. We searched the Cochrane Schizophrenia Group's Register (December 2008) which is based on regular searches of, amongst others, BIOSIS, CENTRAL CINAHL, EMBASE, MEDLINE and PsycINFO. References of all identified studies were inspected for further trials. We also contacted relevant pharmaceutical companies for additional information. All randomised trials comparing levomepromazine with placebo or other antipsychotics for schizophrenia and schizophreniform psychoses were included. Data were extracted independently. For dichotomous outcomes, we calculated relative risk (RR) (random-effects model), 95% confidence intervals (CI) and, where appropriate, number needed to treat (NNT) was calculated. We avoided the use of number needed to harm (NNH), as an alternative we used number needed to treat for an additional beneficial outcome (NNTB) and number needed to treat for an additional harmful outcome (NNTH) to indicate the direction ...Continue Reading

  • References44
  • Citations3

Mentioned in this Paper

Antipsychotic Effect
Other antipsychotics in ATC
Assay OF Haloperidol
Schizophrenia
Clozapine
Methotrimeprazine
Antiparkinson Agents
Haloperidol
Antipsychotic Agents
Typical Antipsychotic [EPC]

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