Levonadifloxacin, a Novel Benzoquinolizine Fluoroquinolone, Modulates Lipopolysaccharide-Induced Inflammatory Responses in Human Whole-Blood Assay and Murine Acute Lung Injury Model.

Antimicrobial Agents and Chemotherapy
Anasuya PatelMahesh Patel

Abstract

Fluoroquinolones are reported to possess immunomodulatory activity; hence, a novel benzoquinolizine fluoroquinolone, levonadifloxacin, was evaluated in lipopolysaccharide-stimulated human whole-blood (HWB) and mouse acute lung injury (ALI) models. Levonadifloxacin significantly mitigated the inflammatory responses in an HWB assay through inhibition of proinflammatory cytokines and in the ALI model by lowering lung total white blood cell count, myeloperoxidase, and cytokine levels. The immunomodulatory effect of levonadifloxacin, along with promising antibacterial activity, is expected to provide clinical benefits in the treatment of infections.

References

Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Mihaela PericPeter C Appelbaum
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Michael R JacobsHabil F Khorakiwala
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Mahesh V PatelPeter C Appelbaum
Jan 15, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P C AppelbaumH F Khorakiwala
Mar 7, 2006·Infection·A Dalhoff
Nov 23, 2006·The Journal of Antimicrobial Chemotherapy·Markus ZeitlingerChristian Joukhadar
Jul 16, 2013·Mediators of Inflammation·Wibke SchulteRichard Bucala
Jan 9, 2015·Cardiovascular & Hematological Disorders Drug Targets·Yelena V Lerman, Minsoo Kim
Nov 12, 2015·World Journal of Gastroenterology : WJG·Pedro ZapaterRubén Francés
Jan 6, 2016·Antimicrobial Agents and Chemotherapy·Kimberly C ClaeysMichael J Rybak
Apr 8, 2017·The Journal of Experimental Medicine·Laurent L ReberStephen J Galli
Aug 16, 2017·Critical Care : the Official Journal of the Critical Care Forum·Ali HassounBruce Friedman
Apr 20, 2018·Medical Sciences : Open Access Journal·Amjad A KhanArshad H Rahmani
Feb 28, 2019·Scientific Reports·Xiaona AnJianbo Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.