Levonorgestrel-releasing intrauterine device is an efficacious contraceptive for women with leiomyoma

The Journal of International Medical Research
Z-W XieJ Chen

Abstract

To evaluate the efficacy of a levonorgestrel-releasing intrauterine device (LNG-IUD) as contraception for women with uterine leiomyoma. Thirty women with uterine leiomyoma requiring contraception were enrolled and had a LNG-IUD inserted. Menstrual blood volume (assessed by a pictorial blood loss assessment chart [PBAC]), haemoglobin concentration, volume of uterus and leiomyoma were determined before and after LNG-IUD insertion. The median (range) PBAC score was 145.0 (60.0-232.0) before LNG-IUD insertion, which significantly decreased to 44.0 (0.0-99.0) and 36.0 (0.0-90.0) after 6 and 12 months of LNG-IUD use, respectively. Prior to LNG-IUD insertion, the median haemoglobin concentration in patients with anaemia was 100.0 (69.0-109.0) g/l and this increased significantly after 6 and 12 months of LNG-IUD use, to 117.5 (101.0-131.0) g/l and 119.5 (108.0-135.0) g/l, respectively. There were no significant changes in uterine or leiomyoma volumes. No patient became pregnant and there were no severe side-effects; one IUD was expulsed. The LNG-IUD may be a safe and effective contraceptive for women of reproductive age with uterine leiomyoma.

References

Jul 1, 1992·Fertility and Sterility·B S Verkauf
Aug 1, 1990·British Journal of Obstetrics and Gynaecology·J M HighamR W Shaw
Oct 19, 2000·Environmental Health Perspectives·M S Rein
Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dirk Wildemeersch, E Schacht
May 10, 2003·Fertility and Sterility·Vera GrigorievaAnton Mikhailov
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A IkomiA Singer
Mar 27, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A KriplaniN Agarwal
Oct 31, 2008·Journal of Minimally Invasive Gynecology·M GunesMetin Kaplan
Aug 5, 2010·Contraception·Lauren B ZapataKathryn M Curtis
Aug 5, 2010·Contraception·Lauren B ZapataKathryn M Curtis
Nov 26, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Gamal H SayedMamdouh M Shaaban

Citations

Feb 12, 2015·Obstetrical & Gynecological Survey·Johannes BitzerIan S Fraser

Methods Mentioned

BETA
contraception
PBAC

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.