Abstract
Women with ovarian cancer have poor survival rates, which have proven difficult to improve; therefore primary prevention is important. The levonorgestrel-releasing intrauterine system (LNG-IUS) prevents endometrial cancer, and recent studies suggested that it may also prevent ovarian cancer, but with a concurrent increased risk of breast cancer. We compared adjusted risks of ovarian, endometrial, and breast cancer in ever users and never users of LNG-IUS. Our study cohort consisted of 104,318 women from the Norwegian Women and Cancer Study, 9144 of whom were ever users and 95,174 of whom were never users of LNG-IUS. Exposure information was taken from self-administered questionnaires, and cancer cases were identified through linkage to the Cancer Registry of Norway. Relative risks (RRs) with 95% confidence intervals (CIs) were estimated with Poisson regression using robust error estimates. Median age at inclusion was 52years and mean follow-up time was 12.5 (standard deviation 3.7) years, for a total of 1,305,435 person-years. Among ever users of LNG-IUS there were 18 cases of epithelial ovarian cancer, 15 cases of endometrial cancer, and 297 cases of breast cancer. When ever users were compared to never users of LNG-IUS, the m...Continue Reading
Citations
Apr 30, 2019·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Anne GompelUNKNOWN European Society of Contraception Expert Group on Hormonal Contraception
Aug 16, 2019·BMJ : British Medical Journal·Anders HusbyMads Melbye
Oct 11, 2019·Obstetrics and Gynecology·Melissa L WongNancy C Chescheir
Sep 13, 2019·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Claire HenryAlec Ekeroma
Dec 26, 2019·Post Reproductive Health·Isaac ManyondaJoseph Onwude
Jan 29, 2020·Human Reproduction Update·Catherine BergeronSarah Maheux-Lacroix
Jan 29, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Livia ConzLuis Otavio Sarian
Sep 11, 2019·Obstetrics and Gynecology·Lindsay J WheelerSaketh R Guntupalli
Mar 11, 2020·Journal of Women's Health·Sarina SchragerDeborah B Ehrenthal
Mar 13, 2020·Clinical Drug Investigation·Nattawut Leelakanok, Janthima Methaneethorn
May 31, 2018·BMC Cancer·Jung-Yoon YooTae Hoon Kim
Nov 15, 2018·Current Oncology Reports·Michelle L MacKintosh, Emma J Crosbie
Oct 26, 2018·Cancer Cytopathology·Bryn Nelson
Jul 25, 2020·Post Reproductive Health·Jo MarsdenUNKNOWN British Menopause Society with acknowledgement to Professor Richard Santen
May 28, 2020·Obstetrics and Gynecology·David ChelmowJulia Sage O'Hara
Jul 8, 2020·Cancers·Atanas Ignatov, Olaf Ortmann
Oct 14, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Jacques BalaylaCristina Mitric
Nov 28, 2020·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Rafael Sánchez-Borrego, Manuel Sánchez-Prieto
Dec 5, 2020·Journal of Women's Health·Kristi Tough DeSapri, Pelin Batur
Oct 14, 2019·Fertility and Sterility·Lee-May ChenTerri Woodard
Oct 2, 2020·Cancer Prevention Research·Abigail E DerbyshireEmma J Crosbie
Mar 3, 2021·Gynecologic Oncology·L BernardC J Reade
Feb 27, 2021·International Journal of Cancer. Journal International Du Cancer·Jiaxi YangKathryn L Terry
Oct 31, 2019·La Presse médicale·Anne Gompel
Apr 28, 2021·BMC Cancer·Pia LeanderssonChrister Borgfeldt
Feb 24, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Minh Tung PhungUNKNOWN Ovarian Cancer Association Consortium
May 11, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Gloria D'AlessandroSimone Ferrero
May 29, 2021·Clinical Breast Cancer·Fabio R SilvaMaria Inês da Rosa
Jul 22, 2021·Reproductive Health·Rebecca GormleyWendy V Norman
Aug 8, 2021·Cancers·Suzanna HuttJayanta Chatterjee
Feb 29, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Kelechi NjokuEmma J Crosbie
Sep 12, 2020·The American Journal of the Medical Sciences·Anahid M PahlawanianAgustin A Garcia
Sep 12, 2021·Cancer Prevention Research·Danbee KangMira Kang