Levosimendan for Pediatric Anomalous Left Coronary Artery From the Pulmonary Artery Undergoing Repair: A Single-Center Experience

Frontiers in Pediatrics
Chunrong WangYuefu Wang

Abstract

Objectives: Our aim was to retrospectively evaluate the benefit of levosimendan in certain complicated congenital heart procedures such as the pediatric anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) with moderate or severe cardiac dysfunction and its repair. Study Design: We enrolled 40 pediatric patients with ALCAPA and moderate or severe left ventricular dysfunction. Patients who had a preoperative left ventricular ejection fraction (LVEF) of 50% or less and had undergone the surgical correction of their coronary artery through cardiopulmonary bypass met the criteria of our study. Twenty patients were given 0.1-0.2 μg/kg/min levosimendan at the induction of anesthesia, which lasted for 24 h. The remaining 20 patients were not given levosimendan. Results: The mean preoperative LVEF in the levosimendan group was significantly lower than that in the non-levosimendan group (22.5 ± 10.7% vs. 31.8 ± 8.1%, p = 0.004). On postoperative day 7, the LVEF in the levosimendan group was still significantly lower (27.1 ± 8.9% vs. 37.5 ± 11.0%, p = 0.002). There was no significant difference in ΔLVEF detected on day 7 [median 30.8%, interquartile range (IQR) -4.4 to 63.5% vs. median 15.1%, IQR -3.5 to 40.0%,...Continue Reading

References

Mar 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·H LaksV Allada
Nov 23, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael ZappitelliGilles Paradis
Mar 27, 2007·The Annals of Thoracic Surgery·Rüdiger LangeChristian Schreiber
Oct 2, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Michael G GaiesJennifer C Hirsch
Sep 11, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Mona MomeniThierry Detaille
May 25, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Evelyn LechnerHans Gombotz
Sep 21, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Robert W HarrisonJohn H Alexander
Jan 23, 2015·Pediatric Cardiology·Clara Vilaboa PedrosaMaría Isabel Martín Herranz
Nov 21, 2015·Current Cardiology Reviews·Heather K Chandler, Roxanne Kirsch
Mar 21, 2017·The New England Journal of Medicine·Rajendra H MehtaUNKNOWN LEVO-CTS Investigators
Mar 23, 2017·The New England Journal of Medicine·Giovanni LandoniUNKNOWN CHEETAH Study Group

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.