Levosimendan infusion improves haemodynamics in elderly heart failure patients undergoing urgent hip fracture repair

European Journal of Anaesthesiology
M PonschabW Plöchl

Abstract

Elderly patients with heart failure undergoing urgent major surgery suffer substantial cardiac morbidity and mortality. Levosimendan, a novel calcium sensitizer, enhances myocardial contractility while simultaneously having vasodilatory and cardioprotective properties. This could be advantageous in perioperative management of heart failure patients. Ten consecutive patients with symptomatic heart failure and left ventricular ejection fraction <35% undergoing urgent hip fracture repair were studied. Levosimendan was administered with an infusion rate of 0.1 microg kg(-1) min(-1) in a total dose of 12.5 mg starting a minimum of 2 h prior to surgery. Haemodynamic parameters were obtained at baseline and at 4, 8, 12, 16, 20, 24, 28, 36 and 48 h after start of levosimendan. B-type natriuretic peptide was measured on admission and after 48 h. Patients were 86 +/- 7 yr (mean +/- SD) of age. Levosimendan significantly increased cardiac index from 2.4 +/- 0.3 L min(-1) m(-2) at baseline to 3.2 +/- 0.6 L min(-1) m(-2) after 24 h by increases in stroke volume index (baseline 27 +/- 5 mL m(-2), after 24 h 37 +/- 10 mL m(-2), P < 0.05). Systemic vascular resistance index significantly decreased from 2718 +/- 841 to 1964 +/- 385 dyn s cm-5 m...Continue Reading

Associated Clinical Trials

Nov 25, 2016·María del Carmen Martín Lorenzo

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Citations

Jun 5, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Wolfgang TollerGiovanni Landoni
Apr 16, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Solomon Aronson, Joseph Varon
Apr 22, 2015·Revista brasileira de anestesiologia·Fabiola Quinteros HinojosaFernando Gilsanz
Mar 12, 2009·Journal of Cardiovascular Pharmacology·Markku S NieminenZoltán Papp
Jun 9, 2009·Current Opinion in Anaesthesiology·Markku Salmenperä, Heidi Eriksson
Sep 30, 2021·BMC Musculoskeletal Disorders·Fei YouXiuwen Zhong
Jul 9, 2009·Current Opinion in Anaesthesiology

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