PMID: 24364085Dec 25, 2013Paper

Levosimendan use decreases atrial fibrillation in patients after coronary artery bypass grafting: a pilot study

The Heart Surgery Forum
Ahmet Feyzi Abacilar, Omer Faruk Dogan

Abstract

Atrial fibrillation (AF) often occurs after coronary artery bypass grafting (CABG) and can result in increased morbidity and mortality due to complications. In the present study, our goal was to investigate whether the use of levosimendan can reduce the frequency of AF after coronary artery bypass grafting in patients with poor left ventricle function. To investigate the effectiveness of levosimendan in the prophylaxis of AF, we conducted a prospective, randomized, placebo-controlled clinical study on 200 consecutive patients in whom we performed elective CABG operations. Baseline characteristics were similar in both groups. A control group of 100 patients were treated with placebo (500 mL saline solution), whereas the levosimendan group (n = 100 patients) was treated with levosimendan. High-sensitivity C-reactive protein, cardiac troponin, and creatine kinase–MB levels were measured before surgery and 5 days postoperatively. AF occurred in 12% of the levosimendan group and 36% of the control group. The occurrence of AF was significantly lower in the levosimendan group (P < 0.05). The duration of AF in the levosimendan group was significantly shorter than that in the control group (4.83 ± 1.12 and 6.50 ± 1.55 hours, respectivel...Continue Reading

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Citations

Mar 4, 2015·International Journal of Cardiology·W TollerA Öwall
Nov 26, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Vladimir V LomivorotovAlexander M Karaskov
Feb 6, 2015·British Journal of Anaesthesia·T GrecoA Zangrillo
Nov 9, 2019·Current Anesthesiology Reports·Peter S BurrageBen O'Brien
May 3, 2018·Interactive Cardiovascular and Thoracic Surgery·María Ángeles TenaFrancisco Portela

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