Levosimendan versus milrinone in neonates and infants after corrective open-heart surgery: a pilot study

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Evelyn LechnerHans Gombotz

Abstract

Low cardiac output syndrome commonly complicates the postoperative course after open-heart surgery in children. To prevent low cardiac output syndrome, prophylactic administration of milrinone after cardiopulmonary bypass is commonly used in small children. The aim of this study was to compare the effect of prophylactically administered levosimendan and milrinone on cardiac index in neonates and infants after corrective open-heart surgery. Prospective, single-center, double-blind, randomized pilot study. Tertiary care center, postoperative pediatric cardiac intensive care unit. After written informed consent, 40 infants undergoing corrective open-heart surgery were included. At weaning from cardiopulmonary bypass, either a 24-hr infusion of 0.1 μg/kg/min levosimendan or of 0.5 μg/kg/min milrinone were administered. Cardiac output was evaluated at 2, 6, 9, 12, 18, 24, and 48 hrs after cardiopulmonary bypass using a transesophageal Doppler technique (Cardio-QP, Deltex Medical, Chichester, UK). Cardiac index was calculated from cardiac output and the patients' respective body surface area. Intention-to-treat data of 39 patients (19 in the levosimendan and 20 in the milrinone group) were analyzed using analysis of variance for repe...Continue Reading

References

Jun 12, 1998·British Journal of Anaesthesia·P D Booker
Jul 23, 2002·Lancet·F FollathSteering Committee and Investigators of the Levosimendan Infusion versus Dobutamine (LIDO) Study
Jan 8, 2003·Circulation·Matti KivikkoWilson S Colucci
Jan 31, 2004·European Journal of Pharmacology·Tia SorsaIlkka Kilpeläinen
Mar 17, 2004·Zeitschrift für Kardiologie·Y C LutherP E Lange
Jun 18, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jan-Peter BraunJianshi Liu
Aug 27, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Maila TuranlahtiErkki Pesonen
May 5, 2006·Journal of Intensive Care Medicine·Jonathan R EganDavid S Winlaw
Aug 4, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Poongundran NamachivayamLara S Shekerdemian
Dec 7, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Evelyn LechnerGerald Tulzer
Sep 25, 2008·European Journal of Pediatrics·Wilhelm Alexander OsthausRobert Sümpelmann
Sep 11, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Mona MomeniThierry Detaille
Jun 8, 2011·Intensive Care Medicine·Winnie Vogt, Stephanie Läer

Citations

Feb 18, 2016·Annals of Intensive Care·Olivier BrissaudKhaldoun Kuteifan
Nov 13, 2015·Expert Review of Cardiovascular Therapy·Mahsun YuerekRobert S Shaddy
May 21, 2015·Indian Journal of Pediatrics·B Vishnu Bhat, Nishad Plakkal
Oct 16, 2012·Journal of Cardiothoracic and Vascular Anesthesia·David T MajureGiovanni Landoni
Dec 30, 2016·World Journal for Pediatric & Congenital Heart Surgery·Pertti K SuominenOtto Rahkonen
Dec 31, 2015·World Journal for Pediatric & Congenital Heart Surgery·Alessandra RizzaPaola Cogo
Jan 30, 2018·The Cochrane Database of Systematic Reviews·Julia SchumannSusanne Unverzagt
Apr 25, 2018·Circulation·Bradley S MarinoAmerican Heart Association Congenital Cardiac Defects Committee of the Council on Cardiovascular Disease in the Young; Counc
Oct 4, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Peta M A AlexanderLara S Shekerdemian
Jul 9, 2013·Interactive Cardiovascular and Thoracic Surgery·Ullas AngadiMohammed F Chowdhry
Jul 6, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Elin M ThorlaciusAlbert Castellheim
Jan 1, 2020·Critical Care : the Official Journal of the Critical Care Forum·Anbiao WangQi Tan
Mar 19, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Tomoyuki KanazawaHiroshi Morimatsu
Apr 19, 2021·Cardiology in the Young·Elizabeth J ThompsonChristoph P Hornik

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