journal cover

Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: Behavioral, electrophysiological, and molecular studies

Hippocampus

Aug 6, 2008

Karem H AlzoubiK A Alkadhi

Abstract

Hypothyroidism induces cognitive impairment in experimental animals and patients. Clinical reports are conflicting about the ability of thyroid hormone replacement therapy to fully restore the hypothyroidism-induced learning and memory impairment. In this study, we investigated the effe...read more

Mentioned in this Paper

Signaling Molecule
Cyclic AMP-Responsive DNA-Binding Protein
Memory Loss
Novothyral
MAPK3 wt Allele
Extracellular
Mitogen-Activated Protein Kinases
Memory Training
Immunoblotting
Hypothyroidism
1
28
Paper Details
References
  • References58
  • Citations60
12345...
  • References58
  • Citations60
12345...

Similar Papers Found In These Feeds

Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

MAPK Pathway

MAPK pathway is a complex signaling pathway that regulates transcription, translation, cell cycle, and proliferation. Targeting this pathway has long been considered a promising strategy for cancer therapy. Here is the latest research on this pathway.

G-Protein-Coupled Receptors

G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research.

Neuronal Plasticity

Neuronal plasticity is the brain’s ability to change its structure and function in response to internal or external factors. Here is the latest research on mechanisms that influence this process.

Synaptic Biochemistry

Synapses are essential for neuronal function. Synaptic loss and alterations are associated with sensory, motor, and cognitive impairments, and have been implicated in several neurodegenerative diseases. Here is the latest research on synaptic biochemistry.

Granule Cell in Hippocampal Processing

Granule cells present in the dentate gyrus of the hippocampus and are essential for memory functioning. These cells release granule molecules that are important factors for information processing and synaptic plasticity. Here is the latest research on granule cell in hippocampal processing.

Memory: Long-Term

Memory refers to the encoding, storage, and retrieval of information. Here is the latest research on aspects that underlie long-term memory formation and loss.

© 2020 Meta ULC. All rights reserved

Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: Behavioral, electrophysiological, and molecular studies

Hippocampus

Aug 6, 2008

Karem H AlzoubiK A Alkadhi

PMID: 18680156

DOI: 10.1002/hipo.20476

Abstract

Hypothyroidism induces cognitive impairment in experimental animals and patients. Clinical reports are conflicting about the ability of thyroid hormone replacement therapy to fully restore the hypothyroidism-induced learning and memory impairment. In this study, we investigated the effe...read more

Mentioned in this Paper

Signaling Molecule
Cyclic AMP-Responsive DNA-Binding Protein
Memory Loss
Novothyral
MAPK3 wt Allele
Extracellular
Mitogen-Activated Protein Kinases
Memory Training
Immunoblotting
Hypothyroidism
1
28

Similar Papers Found In These Feeds

Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

MAPK Pathway

MAPK pathway is a complex signaling pathway that regulates transcription, translation, cell cycle, and proliferation. Targeting this pathway has long been considered a promising strategy for cancer therapy. Here is the latest research on this pathway.

Related Papers

Experimental Neurology

A critical role of CREB in the impairment of late-phase LTP by adult onset hypothyroidism

Experimental NeurologySeptember 6, 2006
Karem H Alzoubi, K A Alkadhi
Paper Details
References
  • References58
  • Citations60
12345...
  • References58
  • Citations60
12345...
/papers/levothyroxin-restores-hypothyroidism-induced/18680156