Levuglandin E2 inhibits mitosis and microtubule assembly

Prostaglandins
K MurthiH Sternlicht

Abstract

Levuglandin E2 (LGE2) is a gamma-keto aldehyde produced by rearrangement of the prostaglandin endoperoxide PGH2 under the aqueous conditions of its biosynthesis. We show that exogenous LGE2 enters cells and efficiently inhibits the first synchronous cell division of fertilized sea urchin eggs. We attribute this inhibition to covalent modification of tubulin and thereby to inhibition of microtubule assembly.

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Citations

Mar 24, 2004·Chemistry and Physics of Lipids·Sean S DaviesL Jackson Roberts
Apr 15, 2004·Free Radical Biology & Medicine·Sean S DaviesL Jackson Roberts
Apr 26, 2008·Molecular & Cellular Proteomics : MCP·Kwok-Peng NgJohn W Crabb
Jan 15, 2005·Antioxidants & Redox Signaling·Robert G Salomon
Jul 21, 2009·Free Radical Biology & Medicine·Sanjoy RoychowdhuryLaura E Nagy
Jul 23, 2005·Annals of the New York Academy of Sciences·Robert G Salomon
Jan 6, 2015·Antioxidants & Redox Signaling·Robert G Salomon, Wenzhao Bi
Sep 8, 2016·Chemical Research in Toxicology·Wenzhao BiRobert G Salomon
Mar 9, 2005·Chemistry and Physics of Lipids·Robert G Salomon
Feb 15, 2017·Journal of Natural Products·Yu-Shiuan ChengRobert G Salomon
Apr 20, 1993·Biochemistry·K K MurthiR G Salomon
Dec 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eugenia PoliakovStanley L Hazen

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