Lewis Acid Catalyzed Annulation of Nitrones with Oxiranes, Aziridines, and Thiiranes

Organic Letters
Stalin R PathipatiNicklas Selander

Abstract

A highly selective Lewis acid catalyzed annulation of three-membered heterocycles with nitrones has been developed. Oxiranes, aziridines, and thiiranes were used as substrates for the synthesis of various six-membered heterocycles using Al or In catalysts. This catalytic protocol demonstrates a broad substrate scope and provides access to new structural motifs in high yields and in excellent selectivity under mild reaction conditions.

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