PMID: 11898554Mar 20, 2002Paper

Lewy bodies and dementia

Current Neurology and Neuroscience Reports
D Galasko

Abstract

The discovery of widely distributed Lewy bodies (LBs) in the brains of patients with dementia has stimulated much clinical and pathologic inquiry. This clinico-pathologic syndrome is now referred to as dementia with Lewy bodies (DLB). Diagnostic criteria for DLB proposed at a workshop in 1995 are receiving detailed scrutiny. The criteria are complex to apply, and appear to have high specificity, but variable sensitivity. Neuropathologic studies have been aided by the development of probes against alpha-synuclein, a key component of LBs. Widespread LBs in limbic or cortical areas contribute to dementia. Pharmacologic management of cognitive and behavioral symptoms in patients with DLB is being explored. There is evidence that cholinesterase inhibitors may have beneficial effects.

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Citations

Jan 31, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sean J CollobyJohn T O'Brien
Apr 10, 2016·Journal of Psychiatric Research·Sean J CollobyJohn-Paul Taylor
Mar 29, 2007·Dementia and Geriatric Cognitive Disorders·Inga LiepeltDaniela Berg
Jul 19, 2003·Current Opinion in Neurology·Diane D Murphy, Bernard Ravina

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