Lewy-body dementia and responsiveness to cholinesterase inhibitors: a paradigm for heterogeneity of Alzheimer's disease?

Trends in Pharmacological Sciences
P LiberiniP Spano

Abstract

The concept of heterogeneity of Alzheimer's disease is based on molecular, neuropathological, clinical and neuropsychological features, and also supported by the observation that Alzheimer's patients differ in their response to pharmacological interventions. Recent investigations evaluating the therapeutic potential of cholinesterase inhibitors have disclosed the existence of at least two subsets of patients with dementia, defined as 'responders' and 'nonresponders' to this therapy. In this article, Paolo Liberini and colleagues suggest that the cluster of responders to the cholinesterase inhibitors might include a significant number of subjects with a rather selective dysfunction of the cholinergic system, as in the case of Lewy-body dementia. A neuropathological demonstration of this correlation should open up new therapeutic perspectives.

References

Sep 1, 1976·Brain : a Journal of Neurology·D M BowenA N Davison
Dec 25, 1976·Lancet·W F Durward, H Harrington
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L GarofaloA C Cuello
Oct 1, 1990·Neurology·H A CrystalL I Wolfson
Oct 1, 1988·Neurology·C R BurkhardtS A Schneck
Jul 30, 1982·Science·R T BartusA S Lippa
Mar 11, 1995·Lancet·K L Davis, P Powchik
May 1, 1993·Journal of Neuropathology and Experimental Neurology·M S PollanenC Bergeron
Jan 15, 1994·Lancet·G P Morgan, J G Williams
Feb 1, 1994·Brain : a Journal of Neurology·M Lauritzen
Nov 5, 1994·Lancet·G R Hilson
Aug 20, 1994·Lancet·G Reynolds
Nov 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·R J EdwardsM C Royston
Mar 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·H FörstlR Levy

❮ Previous
Next ❯

Citations

Feb 1, 1997·Italian Journal of Neurological Sciences·P Liberini
Jan 1, 1997·Clinical Therapeutics·H AllainS Belliard
Jun 26, 2003·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Yuriko TanakaMasaru Takasaki
Apr 22, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L TraykovS Pappata
Aug 11, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Werner Poewe
Mar 30, 2006·Neurobiology of Aging·Haruo HanyuKimihiko Abe
Nov 14, 2007·Expert Review of Neurotherapeutics·Rawan Tarawneh, James E Galvin
Mar 29, 2007·Dementia and Geriatric Cognitive Disorders·Inga LiepeltDaniela Berg
Dec 19, 2001·International Journal of Geriatric Psychiatry·R BarberI G McKeith
May 31, 2007·American Journal of Alzheimer's Disease and Other Dementias·Luca RozziniAlessandro Padovani
Nov 7, 2006·Journal of Geriatric Psychiatry and Neurology·Debby TsuangJames B Leverenz
Aug 12, 1999·Annals of Medicine·D F Brown

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.