PMID: 8604954Mar 11, 1996Paper

Lewy body disease and dementia. A review

Archives of Internal Medicine
S KalraA E Lang

Abstract

Lewy bodies (LBs) are intracytoplasmic neuronal inclusions sometimes found in the brain stem, diencephalon, basal ganglia, and cerebral cortex. Cases designated as diffuse Lewy body disease (DLBD) demonstrate widespread cortical and subcortical Lewy body formation. The fact that DLBD is possibly the second most common cause of dementia after Alzheimer's disease is not generally recognized. We hope to emphasize the importance of this common neurodegenerative disorder by reviewing the literature and our own experience with DLBD. The English-language literature dealing with the clinical and pathological features of DLBD was reviewed. Pathological material from the Canadian Brain Tissue Bank, Toronto, Ontario, was reviewed over a 2-year period from 1991 through 1993. Prominent LB pathology may occur in isolation or mixed with pathological changes seen in Alzheimer's disease. Lewy body diseases include Parkinson's disease that presents with a classic movement disorder and sometimes dementia, and DLBD where LBs occur in a widespread distribution in the cortex in addition to the usual subcortical sites. Diffuse LB disease usually presents with a neurobehavioral syndrome that may include hallucinations, delusions, and psychosis; all pa...Continue Reading

Citations

Jul 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·Z WalkerC L E Katona
Sep 21, 2001·Journal of Geriatric Psychiatry and Neurology·Y Y HsuM W Weiner
Jul 23, 1999·Pharmacotherapy·C H Rojas-Fernandez, C MacKnight
Aug 3, 2010·Postgraduate Medicine·Kannayiram Alagiakrishnan
May 1, 1997·Journal of the American Geriatrics Society·M M CherrierJ L Cummings
Jun 26, 2007·Journal of Women & Aging·Peter C Badgio, Blaise L Worden
Jun 12, 2003·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Holly James WesterveltGeoffrey Tremont

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