Apr 9, 2008

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

Nature Medicine
Jeffrey H KordowerC Warren Olanow

Abstract

Fourteen years after transplantation into the striatum of an individual with Parkinson's disease, grafted nigral neurons were found to have Lewy body-like inclusions that stained positively for alpha-synuclein and ubiquitin and to have reduced immunostaining for dopamine transporter. These pathological changes suggest that Parkinson's disease is an ongoing process that can affect grafted cells in the striatum in a manner similar to host dopamine neurons in the substantia nigra. These findings have implications for cell-based therapies and for understanding the cause of Parkinson's disease.

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  • Citations497

Citations

Mentioned in this Paper

Embryo
SNCA gene
Neostriatum
Ubiquitin
Neurons
Immunocytochemistry
Substantia Nigra Structure
Ubiquitin Activity
Dopamine transporter
Entire Substantia Nigra

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