Lexipafant inhibits postsurgical adhesion formation

The Journal of Surgical Research
Hedef OzgünSerhan Sakarya

Abstract

PAF and its antagonists have been studied in the pathophysiology of various inflammatory conditions. This study investigates the effects of a platelet activating factor antagonist, lexipafant, on peritoneal adhesion formation and wound healing. Forty-eight Wistar albino rats (300-350 g) were divided into four equal groups; adhesion-induced lexipafant (AL), adhesion-induced saline (AS), sham-operated lexipafant (SL), and sham-operated saline (SS). All rats underwent a midline laparotomy under sterile conditions. The anterior wall of the left uterine horn was scraped to cause hemorrhages in adhesion-induced groups. Following peritoneal injections of either saline or lexipafant, the incisions were closed in layers. On the 14th day, the rats were killed and adhesions were scored from 0 (none) to 4 (dense). Tissue samples from the adhesions and the left horn of uterus were examined biochemically for hydroxyproline content, and serum IL-6 levels were determined. The adhesion formation score was significantly increased in the AS group compared to the SL and AL groups (P < 0.001). The IL-6 levels of the AS group were higher than those of the other groups (P < 0.05). There was no significant difference in hydroxyproline content between ...Continue Reading

References

Oct 15, 1985·American Journal of Obstetrics and Gynecology·R P Jansen
Sep 1, 1995·The Journal of Surgical Research·J C LangerG J Pelletier
Nov 1, 1993·The Australian and New Zealand Journal of Surgery·M R CoxA W Heinz
Jun 1, 1996·Clinical Biochemistry·G K Reddy, C S Enwemeka
Nov 5, 1997·Clinical Immunology and Immunopathology·B E Barton
Jan 28, 1998·American Journal of Surgery·Y GaliliY Kluger
Aug 6, 1998·The British Journal of Surgery·A G Hill, G L Hill
Sep 10, 1998·American Journal of Obstetrics and Gynecology·H B ZeynelogluA Arici
Jun 22, 1999·Human Reproduction·B VuralC Sökmensüer
Sep 30, 1999·Gastroenterology Clinics of North America·C W Imrie, C J McKay

❮ Previous
Next ❯

Citations

Aug 30, 2008·World Journal of Gastroenterology : WJG·Ronan A Cahill, H Paul Redmond
Jun 9, 2007·Fertility and Sterility·Saman NikeghbalianHamed Jalaeian
Jun 5, 2007·The Journal of Surgical Research·Nir WasserbergAndreas G Tzakis
Jul 20, 2010·The Journal of Surgical Research·Johanne D CashmanChristopher M K Springate

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.